Sugi Predict

Sugi Predict / Compounds / SCHEMBL1557065

SCHEMBL1557065

SCHEMBL1557065

Cn1nnnc1-c1ccc(Br)cn1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMO O15229 1/20 0.41
▸ HIF1A Q16665 1/20 0.39
▸ NPSR1 Q6W5P4 1/20 0.39
▸ RXFP1 Q9HBX9 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ PDE10A Q9Y233 1/20 0.35
▸ KDM4E B2RXH2 2/20 0.34
▸ PDE2A O00408 1/20 0.33
▸ GBA1 P04062 1/20 0.33
▸ CCR1 P32246 1/20 0.32
▸ CCR5 P51681 1/20 0.32
▸ CCR8 P51685 1/20 0.32
▸ HDAC6 Q9UBN7 1/20 0.32
▸ ADRB2 P07550 1/20 0.32
▸ HTT P42858 1/20 0.32
▸ PAX8 Q06710 1/20 0.32
▸ PIP4K2C Q8TBX8 1/20 0.32
▸ CA2 P00918 1/20 0.32
▸ ALDH1A1 P00352 2/20 0.31
▸ HTR2C P28335 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30094777 1.00 KMO (0.41) KMOHIF1ANPSR1RXFP1SMN1; SMN2
SCHEMBL14949186 0.82 CCR1 (0.54) KMOSMN1; SMN2PDE10ACCR1CCR5
SCHEMBL1656606 0.79 KMO (0.41) KMOHIF1ANPSR1RXFP1SMN1; SMN2
SCHEMBL14946750 0.77 KMO (0.40) KMONPSR1SMN1; SMN2PDE10AKDM4E
SCHEMBL29454964 0.77 KDM4E (0.44) KMONPSR1SMN1; SMN2KDM4EPDE2A
SCHEMBL24143101 0.76 MMP2 (0.35) HIF1ANPSR1RXFP1SMN1; SMN2HTT
SCHEMBL25808660 0.76 DCUN1D1 (0.38) GBA1HTTALDH1A1
SCHEMBL5221832 0.74 PDE10A (0.41) KMOSMN1; SMN2PDE10AALDH1A1
SCHEMBL420682 0.74 SMN1; SMN2 (0.52) KMOHIF1ANPSR1RXFP1SMN1; SMN2
SCHEMBL13430045 0.74 MYC (0.34) SMN1; SMN2KDM4EPDE2AGBA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115385959-A High-purity tedizolid phosphate and preparation method thereof 浙江尖峰药业有限公司 2022-11-25 — — CN claimed
CN-110078764-B Preparation method of oxazolidinone compound 博瑞生物医药（苏州）股份有限公司 2021-10-26 — — CN disclosed
US-20210121449-A1 NOVEL OXAZOLIDINONE DERIVATIVES DONG A ST CO LTD (KR) 2021-04-29 — — US disclosed
US-20200078345-A1 NOVEL OXAZOLIDINONE DERIVATIVES DONG A ST CO LTD (KR) 2020-03-12 — — US disclosed
US-20180344716-A1 NOVEL OXAZOLIDINONE DERIVATIVES DONG A ST CO LTD (KR) 2018-12-06 — — US disclosed
EP-2185549-B1 ANTIMICROBIAL ORTHO-FLUOROPHENYL OXAZOLIDINONES FOR TREATMENT OF BACTERIAL INFECTIONS MICURX PHARMACEUTICALS INC (KY) 2018-10-03 — — EP disclosed
US-20170333414-A1 NOVEL OXAZOLIDINONE DERIVATIVES DONG A ST CO LTD (KR) 2017-11-23 — — US disclosed
US-20170049763-A1 NOVEL OXAZOLIDINONE DERIVATIVES DONG A ST CO LTD (KR) 2017-02-23 — — US disclosed
US-9163043-B2 Oxazolidinone derivatives DONG-A ST CO., LTD. (KR) 2015-10-20 — — US disclosed
US-20140350059-A1 NOVEL OXAZOLIDINONE DERIVATIVES DONG A ST CO LTD (KR) 2014-11-27 — — US disclosed
EP-1289984-A4 NOVEL OXAZOLIDINONE DERIVATIVES AND A PROCESS FOR THE PREPARATION THEREOF DONG A PHARM CO LTD (KR) 2004-11-24 — — EP disclosed
WO-2004056816-A1 ANTIBACTERIAL OXAZOLIDINONES ASTRAZENECA AB (SE) 2004-07-08 — — WO disclosed
WO-2004056819-A1 OXAZOLIDINONE DERIVATIVES AS ANTIBACTERIAL AGENTS ASTRAZENECA AB (SE) 2004-07-08 — — WO disclosed
WO-2004056818-A1 OXAZOLIDINONE DERIVATIVES AS ANTIBACTERIAL ASTRAZENECA AB (SE) 2004-07-08 — — WO disclosed
WO-2004048350-A2 OXAZOLIDINONES AS ANTIBACTERIAL AGENTS ASTRAZENECA AB (SE) 2004-06-10 — — WO disclosed
US-6689779-B2 PYRIDINE OR PYRIMIDINE SUBSTITUTED; ANTIBACTERIAL ACTIVITY; LOW TOXICITY DONG A PHARM. CO., LTD. (KR) 2004-02-10 — — US disclosed
US-20030166620-A1 Novel oxazolidinone derivatives and a process for the preparation thereof DONG A PHARM. CO., LTD. (KR) 2003-09-04 — — US disclosed
CN-1433413-A Oxazolidinone derivatives and process for their preparation DONG A PHARM CO LTD (KR) 2003-07-30 — — CN disclosed
EP-1289984-A1 NOVEL OXAZOLIDINONE DERIVATIVES AND A PROCESS FOR THE PREPARATION THEREOF Dong A Pharmaceutical Co. Ltd. (KR) 2003-03-12 — — EP disclosed
WO-2001094342-A1 NOVEL OXAZOLIDINONE DERIVATIVES AND A PROCESS FOR THE PREPARATION THEREOF DONG A PHARM. CO., LTD. (KR) 2001-12-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030166620-A1 Novel oxazolidinone derivatives and a process for the preparation thereof OXA1L, ODC1, PDCD4 KMO 1450/4885HIF1A 2791/4885NPSR1 4235/4885
US-20170049763-A1 NOVEL OXAZOLIDINONE DERIVATIVES ALPI, OXA1L, SI KMO 797/4885HIF1A 986/4885NPSR1 4722/4885
US-20210121449-A1 NOVEL OXAZOLIDINONE DERIVATIVES ALPI, OXA1L, SI KMO 797/4885HIF1A 986/4885NPSR1 4722/4885
US-20200078345-A1 NOVEL OXAZOLIDINONE DERIVATIVES ALPI, OXA1L, SI KMO 797/4885HIF1A 986/4885NPSR1 4722/4885
US-20170333414-A1 NOVEL OXAZOLIDINONE DERIVATIVES ALPI, OXA1L, SI KMO 797/4885HIF1A 986/4885NPSR1 4722/4885
US-20140350059-A1 NOVEL OXAZOLIDINONE DERIVATIVES ALPI, OXA1L, SI KMO 797/4885HIF1A 986/4885NPSR1 4722/4885
US-20180344716-A1 NOVEL OXAZOLIDINONE DERIVATIVES ALPI, OXA1L, SI KMO 797/4885HIF1A 986/4885NPSR1 4722/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.