Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.59 |
| ▸ | HRH1 | P35367 | 11/20 | 0.55 |
| ▸ | HTR6 | P50406 | 11/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.54 |
| ▸ | HTR2A | P28223 | 3/20 | 0.54 |
| ▸ | HTR2C | P28335 | 3/20 | 0.54 |
| ▸ | HTR7 | P34969 | 3/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.54 |
| ▸ | DRD2 | P14416 | 2/20 | 0.54 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.51 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.51 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.51 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.51 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.51 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 2/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14326090 | 0.91 | HTR6 (0.64) | HDAC6HDAC1HRH1HTR6ADRA2A | |
| SCHEMBL2173158 | 0.91 | HDAC6 (0.62) | HDAC6HDAC1HRH1HTR6ADRA2A | |
| SCHEMBL2190354 | 0.89 | HTR6 (0.65) | HDAC6HDAC1HRH1HTR6ADRA2A | |
| SCHEMBL12480629 | 0.88 | HDAC6 (0.51) | HDAC6HDAC1HRH1HTR6ADRA2A | |
| SCHEMBL169172 | 0.88 | HTR6 (0.58) | HDAC6HDAC1HRH1HTR6ADRA2A | |
| SCHEMBL2186326 | 0.87 | HTR6 (0.66) | HDAC6HDAC1HRH1HTR6ADRA2A | |
| SCHEMBL12480988 | 0.86 | HDAC6 (0.51) | HDAC6HDAC1HRH1HTR6ADRA2A | |
| SCHEMBL167363 | 0.85 | HTR6 (0.67) | HDAC6HDAC1HRH1HTR6ADRA2A | |
| SCHEMBL167362 | 0.85 | HTR6 (0.67) | HDAC6HDAC1HRH1HTR6ADRA2A | |
| SCHEMBL168926 | 0.85 | HTR6 (0.67) | HDAC6HDAC1HRH1HTR6ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150315188-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF HYPERTENSION | MEDIVATION TECHNOLOGIES, INC. | 2015-11-05 | — | — | US | disclosed |
| EP-2887805-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF HYPERTENSION | Medivation Technologies, Inc. (US) | 2015-07-01 | — | — | EP | disclosed |
| WO-2014031165-A1 | COMPOUNDS AND METHODS OF TREATING DIABETES | MEDIVATION TECHNOLOGIES, INC. (US) | 2014-02-27 | — | — | WO | disclosed |
| WO-2014031170-A1 | PYRIDO[4,3-B]INDOLE AND PYRIDO[3,4-B]INDOLE DERIVATIVES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2014-02-27 | — | — | WO | disclosed |
| WO-2014031167-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF HYPERTENSION | MEDIVATION TECHNOLOGIES, INC. (US) | 2014-02-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150315188-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF HYPERTENSION | ADRB2, ADRA2B, ADRB1 | HDAC6 2617/4885HDAC1 1104/4885HRH1 83/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.