⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4663207 | 0.76 | AURKA (0.33) | — | |
| SCHEMBL1038873 | 0.76 | — | — | |
| SCHEMBL3152148 | 0.69 | LMNA (0.35) | — | |
| SCHEMBL28947028 | 0.66 | COMT (0.48) | — | |
| SCHEMBL7189439 | 0.58 | HDAC8 (0.34) | — | |
| SCHEMBL1037428 | 0.57 | ALDH1A1 (0.31) | — | |
| SCHEMBL10370901 | 0.57 | AURKA (0.34) | — | |
| SCHEMBL7195400 | 0.57 | DAO (0.34) | — | |
| SCHEMBL1581968 | 0.57 | NOTUM (0.42) | — | |
| SCHEMBL9217273 | 0.57 | DAO (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2892904-B1 | HIGHLY SELECTIVE C-MET INHIBITORS AS ANTICANCER AGENTS | CB THERAPEUTICS INC (KY) | 2018-10-17 | — | — | EP | disclosed |
| US-9695175-B2 | Highly selective c-Met inhibitors as anticancer agents | CB THERAPEUTICS INC. (KY) | 2017-07-04 | — | — | US | disclosed |
| US-20150218171-A1 | HIGHLY SELECTIVE C-MET INHIBITORS AS ANTICANCER AGENTS | APOLLOMICS INC. | 2015-08-06 | — | — | US | disclosed |
| EP-2892904-A1 | HIGHLY SELECTIVE C-MET INHIBITORS AS ANTICANCER AGENTS | Crown Bioscience Inc. (Taiwan) (CN) | 2015-07-15 | — | — | EP | disclosed |
| WO-2014032498-A1 | HIGHLY SELECTIVE C-MET INHIBITORS AS ANTICANCER AGENTS | CROWN BIOSCIENCE INC. (TAICANG) (CN) | 2014-03-06 | — | — | WO | disclosed |