Sugi Predict

Sugi Predict / Compounds / SCHEMBL15577321

SCHEMBL15577321

SCHEMBL15577321

O=c1[nH]ncc2cc(F)ccc12

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.56
▸ PARP1 P09874 2/20 0.56
▸ PRKCI P41743 1/20 0.56
▸ PDE4B Q07343 1/20 0.56
▸ HSD17B10 Q99714 1/20 0.56
▸ TDP1 Q9NUW8 1/20 0.56
▸ DAO P14920 2/20 0.43
▸ TYMS P04818 1/20 0.42
▸ METAP2 P50579 1/20 0.41
▸ LMNA P02545 2/20 0.41
▸ POLB P06746 1/20 0.41
▸ MAPT P10636 1/20 0.41
▸ KDM4E B2RXH2 2/20 0.38
▸ SGK1 O00141 1/20 0.38
▸ CTNNB1 P35222 1/20 0.38
▸ WNT3A P56704 1/20 0.38
▸ MET P08581 2/20 0.38
▸ MEN1 O00255 1/20 0.38
▸ TSHR P16473 1/20 0.38
▸ KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29655244 1.00 ALDH1A1 (0.56) ALDH1A1PARP1PRKCIPDE4BHSD17B10
SCHEMBL21917350 0.85 PARP1 (0.56) ALDH1A1PARP1PRKCIPDE4BHSD17B10
SCHEMBL29390884 0.85 PARP1 (0.56) ALDH1A1PARP1PRKCIPDE4BHSD17B10
SCHEMBL31331121 0.78 PARP1 (0.56) ALDH1A1PARP1PRKCIPDE4BHSD17B10
SCHEMBL396016 0.78 METAP2 (0.56) ALDH1A1PARP1PRKCIPDE4BHSD17B10
SCHEMBL25184048 0.78 ALDH1A1 (0.56) ALDH1A1PARP1PRKCIPDE4BHSD17B10
SCHEMBL29735151 0.78 METAP2 (0.56) ALDH1A1PARP1PRKCIPDE4BHSD17B10
SCHEMBL1008698 0.78 ALDH1A1 (0.56) ALDH1A1PARP1PRKCIPDE4BHSD17B10
SCHEMBL4060395 0.78 PARP1 (0.61) ALDH1A1PARP1PRKCIPDE4BHSD17B10
SCHEMBL30375696 0.78 ALDH1A1 (0.56) ALDH1A1PARP1PRKCIPDE4BHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260035354-A1 PIPERIDINEDIONE DERIVATIVES INNOCURE THERAPEUTICS, INC. (KR) 2026-02-05 — — US disclosed
US-12384756-B2 Piperidinedione derivatives INNOCURE THERAPEUTICS, INC. (KR) 2025-08-12 — — US disclosed
US-20240190842-A1 SUBSTITUTED QUINOLINONE-8-CARBONITRILE DERIVATIVES HAVING ANDROGEN DEGRADATION ACTIVITY AND USES THEREOF ACCUTAR BIOTECHNOLOGY INC. (US) 2024-06-13 — — US disclosed
WO-2024112122-A1 DEGRADER FOR DEGRADING BRD PROTEIN AND PHARMACEUTICAL COMPOSITION CONTAINING SAME 주식회사 이노큐어테라퓨틱스 2024-05-30 — — WO disclosed
WO-2024112119-A1 DEGRADER FOR DECOMPOSING CMET PROTEIN, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 주식회사 이노큐어테라퓨틱스 2024-05-30 — — WO disclosed
WO-2024112119-A1 DEGRADER FOR DECOMPOSING CMET PROTEIN, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 주식회사 이노큐어테라퓨틱스 2024-05-30 — — WO disclosed
WO-2024112120-A1 DEGRADER INCLUDING NOVEL C-MET PROTEIN LIGAND AND PHARMACEUTICAL COMPOSITION INCLUDING SAME 주식회사 이노큐어테라퓨틱스 2024-05-30 — — WO disclosed
WO-2024112120-A1 DEGRADER INCLUDING NOVEL C-MET PROTEIN LIGAND AND PHARMACEUTICAL COMPOSITION INCLUDING SAME 주식회사 이노큐어테라퓨틱스 2024-05-30 — — WO disclosed
WO-2024102784-A1 SUBSTITUTED QUINOLINONE-8-CARBONITRILE DERIVATIVES HAVING ANDROGEN DEGRADATION ACTIVITY AND USES THEREOF ACCUTAR BIOTECHNOLOGY, INC. (US) 2024-05-16 — — WO disclosed
US-11767312-B2 Phthalazinone compound, and preparation method therefor and medical use thereof GENENTECH, INC. (US) 2023-09-26 — — US disclosed
EP-4116298-A1 PIPERIDINEDIONE DERIVATIVE Innocure Therapeutics, Inc. (KR) 2023-01-11 — — EP disclosed
US-9499548-B2 Inhibitors of bruton's tyrosine kinase HOFFMANN-LA ROCHE INC. (US) 2016-11-22 — — US disclosed
US-9499548-B2 Inhibitors of bruton's tyrosine kinase HOFFMANN-LA ROCHE INC. (US) 2016-11-22 — — US disclosed
US-9499548-B2 Inhibitors of bruton's tyrosine kinase HOFFMANN-LA ROCHE INC. (US) 2016-11-22 — — US disclosed
US-20150210704-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE HOFFMANN-LA ROCHE INC. (US) 2015-07-30 — — US disclosed
US-20150210704-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE HOFFMANN-LA ROCHE INC. (US) 2015-07-30 — — US disclosed
US-20150210704-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE HOFFMANN-LA ROCHE INC. (US) 2015-07-30 — — US disclosed
EP-2895473-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE F. Hoffmann-La Roche AG (CH) 2015-07-22 — — EP disclosed
WO-2014040965-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE F. HOFFMANN-LA ROCHE AG (CH) 2014-03-20 — — WO disclosed
WO-2014040965-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE F. HOFFMANN-LA ROCHE AG (CH) 2014-03-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240190842-A1 SUBSTITUTED QUINOLINONE-8-CARBONITRILE DERIVATIVES HAVING ANDROGEN DEGRADATION ACTIVITY AND USES THEREOF AR, NR5A1, CYP19A1 ALDH1A1 321/4885PARP1 471/4885PRKCI 2014/4885
US-20260035354-A1 PIPERIDINEDIONE DERIVATIVES CRBN, PSMC1, PSME3 ALDH1A1 3619/4885PARP1 726/4885PRKCI 304/4885
US-11767312-B2 Phthalazinone compound, and preparation method therefor and medical use thereof CYP17A1, AR, NR5A1 ALDH1A1 490/4885PARP1 3307/4885PRKCI 4402/4885
US-20150210704-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE BTK, SYK, LYN ALDH1A1 3540/4885PARP1 1781/4885PRKCI 196/4885
US-12384756-B2 Piperidinedione derivatives CRBN, CUL1, PSMB10 ALDH1A1 2741/4885PARP1 1721/4885PRKCI 1803/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.