Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LPO | P22079 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.31 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.31 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.31 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL611873 | 0.76 | ADORA2B (0.59) | ADORA2AADORA2BMAPTALDH1A1 | |
| SCHEMBL27398195 | 0.64 | ADORA2B (0.57) | KDM4EADORA2AADORA2BMAPTALDH1A1 | |
| SCHEMBL22729820 | 0.63 | BRD4 (0.42) | SMN1; SMN2KDM4ECA1MAPTALDH1A1 | |
| SCHEMBL17975077 | 0.61 | CECR2 (0.45) | SMN1; SMN2KDM4ECA1ALDH1A1HPGD | |
| SCHEMBL20927158 | 0.59 | KDM4E (0.52) | SMN1; SMN2LPOPTGS1KDM4ECA1 | |
| SCHEMBL21144481 | 0.58 | HPGD (0.67) | SMN1; SMN2KDM4EADORA2ACA1MAPT | |
| SCHEMBL2632820 | 0.58 | YTHDF2 (0.52) | SMN1; SMN2LPOPTGS1KDM4ECA1 | |
| SCHEMBL12809489 | 0.58 | GDA (0.39) | SMN1; SMN2KDM4EADORA2AMAPTALDH1A1 | |
| SCHEMBL15030952 | 0.57 | SMN1; SMN2 (0.31) | SMN1; SMN2KDM4EMAPTALDH1A1 | |
| SCHEMBL10005933 | 0.57 | HPGD (0.70) | SMN1; SMN2KDM4EADORA2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2708538-B1 | Process for preparing fused pyrimidine-dione derivatives, useful as as TRPA1 modulators | GLENMARK PHARMACEUTICALS SA (CH) | 2015-08-12 | — | — | EP | disclosed |
| EP-2708538-A1 | Process for preparing fused pyrimidine-dione derivatives, useful as as TRPA1 modulators | Glenmark Pharmaceuticals S.A. (CH) | 2014-03-19 | — | — | EP | disclosed |