Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.31 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 3/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12164236 | 0.95 | MET (0.32) | METGPR55ALDH1A1TSHRP2RX3 | |
| SCHEMBL473920 | 0.95 | MET (0.32) | METGPR55ALDH1A1TSHRP2RX3 | |
| SCHEMBL12164237 | 0.87 | PTGER4 (0.33) | GPR55LRRK2 | |
| SCHEMBL473996 | 0.87 | PTGER4 (0.33) | GPR55LRRK2 | |
| SCHEMBL15520201 | 0.87 | GPR55 (0.32) | GPR55LMNALRRK2MEN1KMT2A | |
| SCHEMBL473965 | 0.86 | LMNA (0.34) | METGPR55ALDH1A1TSHRP2RX3 | |
| SCHEMBL12164178 | 0.86 | LMNA (0.41) | METALDH1A1TSHRP2RX3LMNA | |
| SCHEMBL12164179 | 0.86 | LMNA (0.34) | METGPR55ALDH1A1TSHRP2RX3 | |
| SCHEMBL473932 | 0.86 | LMNA (0.41) | METALDH1A1TSHRP2RX3LMNA | |
| SCHEMBL15519897 | 0.84 | KMO (0.32) | GPR55LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411365-B1 | 2,3-DIARYL- OR HETEROARYL-SUBSTITUTED 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2014-03-19 | — | — | EP | disclosed |