Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26434787 | 0.93 | MRGPRX4 (0.58) | MRGPRX4LMNAPOLBMAPTSTAT3 | |
| SCHEMBL22381399 | 0.88 | BRD4 (0.52) | MRGPRX4LMNAPOLBMAPTSTAT3 | |
| SCHEMBL16210864 | 0.87 | MRGPRX4 (0.53) | MRGPRX4LMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL171841 | 0.86 | MRGPRX4 (0.68) | MRGPRX4MAPTSTAT3HTTSMN1; SMN2 | |
| SCHEMBL17858626 | 0.83 | MRGPRX4 (0.53) | MRGPRX4LMNAPOLBMAPTSTAT3 | |
| SCHEMBL19242940 | 0.83 | ACHE (0.53) | LMNAPOLBMAPTSMN1; SMN2BRD4 | |
| SCHEMBL257777 | 0.83 | MRGPRX4 (0.57) | MRGPRX4LMNAHTTPTGER1FFAR4 | |
| SCHEMBL19374625 | 0.83 | MRGPRX4 (0.50) | MRGPRX4POLBMAPTMAPK14ALDH1A1 | |
| SCHEMBL16210297 | 0.83 | MRGPRX4 (0.53) | MRGPRX4LMNAMAPTHTTPTGER1 | |
| SCHEMBL26698908 | 0.83 | MRGPRX4 (0.56) | MRGPRX4LMNAMAPTHTTBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855627-B1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | MERCK PATENT GMBH (DE) | 2017-09-20 | — | — | EP | disclosed |
| US-20150175886-A1 | MESOGENIC MEDIA AND LIQUID CRYSTAL DISPLAY | MERCK PATENT GMBH (DE) | 2015-06-25 | — | — | US | disclosed |
| WO-2013174481-A1 | MESOGENIC MEDIA AND LIQUID CRYSTAL DISPLAY | MERCK PATENT GMBH (DE) | 2013-11-28 | — | — | WO | disclosed |