Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15599157 | 0.88 | SMN1; SMN2 (0.39) | PTGS2SMN1; SMN2MRGPRX4LMNACYP1A2 | |
| SCHEMBL15599257 | 0.82 | MAPK1 (0.43) | PTGS2AAK1SMN1; SMN2 | |
| SCHEMBL24599916 | 0.81 | SSTR4 (0.44) | PTGS2AAK1SMN1; SMN2MRGPRX4LMNA | |
| SCHEMBL16175019 | 0.78 | RAB9A (0.39) | AAK1SMN1; SMN2MRGPRX4LMNACYP1A2 | |
| SCHEMBL17244901 | 0.78 | AAK1 (0.39) | AAK1SMN1; SMN2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL15599248 | 0.76 | CSNK2A1 (0.34) | PTGS2SMN1; SMN2MRGPRX4LMNARXRA | |
| SCHEMBL16770601 | 0.76 | SMN1; SMN2 (0.37) | PTGS2SMN1; SMN2MRGPRX4LMNACYP1A2 | |
| SCHEMBL18400155 | 0.76 | PTGS2 (0.36) | PTGS2AAK1SMN1; SMN2LMNACYP1A2 | |
| SCHEMBL10332075 | 0.75 | SMN1; SMN2 (0.39) | PTGS2SMN1; SMN2LMNA | |
| SCHEMBL21031212 | 0.73 | HCRTR1 (0.44) | SMN1; SMN2LMNARXRAGRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9550775-B2 | Substituted triazolopyridines and methods of use thereof | GENENTECH, INC. (US) | 2017-01-24 | — | — | US | disclosed |
| WO-2014153037-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2014-09-25 | — | — | WO | disclosed |
| WO-2014144545-A2 | SUBSTITUTED BENZOXAZOLES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014008458-A2 | N-SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2014-01-09 | — | — | WO | disclosed |