Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15094149 | 0.87 | RAB9A (0.43) | RAB9AMRGPRX4MAPK1SMN1; SMN2SCN9A | |
| SCHEMBL15094325 | 0.84 | RAB9A (0.42) | RAB9AMRGPRX4MAPK1SMN1; SMN2SCN9A | |
| SCHEMBL363857 | 0.81 | SCN9A (0.49) | RAB9AMRGPRX4MAPK1SMN1; SMN2SCN9A | |
| SCHEMBL24599916 | 0.81 | SSTR4 (0.44) | MRGPRX4SMN1; SMN2SSTR4AAK1LMNA | |
| SCHEMBL15599247 | 0.78 | PTGS2 (0.36) | MRGPRX4SMN1; SMN2SSTR4AAK1LMNA | |
| SCHEMBL365031 | 0.77 | RAB9A (0.39) | RAB9AMRGPRX4MAPK1SMN1; SMN2SCN9A | |
| SCHEMBL17244901 | 0.77 | AAK1 (0.39) | SMN1; SMN2SSTR4AAK1CYP1A2CYP3A4 | |
| SCHEMBL16177396 | 0.74 | RORC (0.41) | RAB9AMRGPRX4MAPK1SMN1; SMN2LMNA | |
| SCHEMBL16175131 | 0.73 | SCN9A (0.44) | RAB9AMRGPRX4MAPK1SMN1; SMN2SCN9A | |
| SCHEMBL16240182 | 0.72 | SCN9A (0.45) | RAB9AMRGPRX4MAPK1SMN1; SMN2SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593431-B1 | N-SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | PFIZER LTD (GB) | 2014-11-19 | — | — | EP | disclosed |
| EP-2593432-B1 | N-SULFONYLBENZAMIDE DERIVATIVES USEFUL AS VOLTAGE GATED SODIUM CHANNEL INHIBITORS | PFIZER LTD (GB) | 2014-10-22 | — | — | EP | disclosed |