Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 9/20 | 0.57 |
| ▸ | GABRD | O14764 | 9/20 | 0.57 |
| ▸ | GABRA1 | P14867 | 9/20 | 0.57 |
| ▸ | GABRB1 | P18505 | 9/20 | 0.57 |
| ▸ | GABRG2 | P18507 | 9/20 | 0.57 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.57 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.57 |
| ▸ | GABRA3 | P34903 | 9/20 | 0.57 |
| ▸ | GABRA2 | P47869 | 9/20 | 0.57 |
| ▸ | GABRB2 | P47870 | 9/20 | 0.57 |
| ▸ | GABRA4 | P48169 | 9/20 | 0.57 |
| ▸ | GABRE | P78334 | 9/20 | 0.57 |
| ▸ | GABRA6 | Q16445 | 9/20 | 0.57 |
| ▸ | GABRG1 | Q8N1C3 | 9/20 | 0.57 |
| ▸ | GABRG3 | Q99928 | 9/20 | 0.57 |
| ▸ | GABRQ | Q9UN88 | 9/20 | 0.57 |
| ▸ | PARG | Q86W56 | 3/20 | 0.53 |
| ▸ | AURKA | O14965 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17001625 | 0.83 | PARG (0.59) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL17001626 | 0.83 | GABRP (0.52) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL16997503 | 0.82 | GABRP (0.53) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL15599481 | 0.81 | PARG (0.57) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL15599478 | 0.81 | LMNA (0.53) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL17845339 | 0.81 | GABRP (0.60) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL15599483 | 0.78 | PARG (0.47) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL4161621 | 0.72 | GABRP (0.56) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL30615405 | 0.71 | HSP90AA1 (0.52) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL17845556 | 0.71 | PARG (0.53) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9505749-B2 | Quinazolinone compounds and derivatives thereof | AMGEN INC. (US) | 2016-11-29 | — | — | US | disclosed |
| US-20150225396-A1 | Quinazolinone Compounds and Derivatives Thereof | AMGEN INC. | 2015-08-13 | — | — | US | disclosed |
| WO-2014036022-A1 | QUINAZOLINONE COMPOUNDS AND DERIVATIVES THEREOF | AMGEN INC. (US) | 2014-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225396-A1 | Quinazolinone Compounds and Derivatives Thereof | TNKS, TPI1, TNKS1BP1 | GABRP 4254/4885GABRD 4474/4885GABRA1 4473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.