Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGB1 | P09429 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.47 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.47 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.47 |
| ▸ | ALB | P02768 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.45 |
| ▸ | HNF4A | P41235 | 1/20 | 0.44 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2473330 | 0.98 | HMGB1 (0.56) | HMGB1ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL6447233 | 0.93 | HMGB1 (0.54) | HMGB1ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL633197 | 0.91 | HMGB1 (0.67) | HMGB1ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL29697016 | 0.91 | HMGB1 (0.67) | HMGB1ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL9109 | 0.85 | ALDH1A1 (0.63) | HMGB1ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL29633266 | 0.85 | ALDH1A1 (0.63) | HMGB1ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL1396288 | 0.83 | HPGD (0.62) | HMGB1ALDH1A1HPGDHSD17B10KDM4E | |
| Ammonia Solution, Strong SCHEMBL7767435 | 0.83 | ALDH1A1 (0.61) | HMGB1ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL3332893 | 0.83 | ALDH1A1 (0.61) | HMGB1ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL17200169 | 0.83 | ALDH1A1 (0.61) | HMGB1ALDH1A1HPGDHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2863921-B1 | POLYMER-NSAID CONJUGATE | POLYACTIVA PTY LTD (AU) | 2018-04-18 | — | — | EP | claimed |
| EP-1154999-B1 | NITROXYDERIVATIVES HAVING ANTIINFLAMMATORY, ANALGESIC AND ANTITHROMBOTIC ACTIVITY | NICOX SA (FR) | 2009-04-15 | — | — | EP | claimed |
| EP-0759899-A1 | NITRO COMPOUNDS AND THEIR COMPOSITIONS HAVING ANTI-INFLAMMATORY, ANALGESIC AND ANTI-THROMBOTIC ACITIVITIES | NICOX S.A. (FR) | 1997-03-05 | — | — | EP | claimed |
| EP-2303327-A2 | NIACIN AND NSAID FOR COMBINATION THERAPY | Cerenis Therapeutics S.A. (FR) | 2011-04-06 | — | — | EP | disclosed |
| US-20100015220-A1 | NIACIN AND NSAID COMBINATION THERAPY | FLAMEL TECHNOLOGIES (FR) | 2010-01-21 | — | — | US | disclosed |
| WO-2009142731-A2 | NIACIN AND NSAID COMBINATION THERAPY | CERENIS THERAPEUTICS S.A. (FR) | 2009-11-26 | — | — | WO | disclosed |
| EP-0169465-B1 | MIXTURE OF PYRIMIDO-PYRIMIDINES AND O-ACETYL-SALICYLIC ACID, OR THEIR PHARMACOLOGICALLY ACCEPTABLE SALTS, AND ITS USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-02-28 | — | — | EP | disclosed |
| EP-0169465-A2 | Mixture of pyrimido-pyrimidines and O-acetyl-salicylic acid, or their pharmacologically acceptable salts, and its use | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-01-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100015220-A1 | NIACIN AND NSAID COMBINATION THERAPY | NNT, NAPRT, NAMPT | HMGB1 328/4885ALDH1A1 581/4885HPGD 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.