Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL9 | O00512 | 1/20 | 0.60 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | MGLL | Q99685 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alcohol SCHEMBL20595561 | 0.88 | BCL9 (0.66) | BCL9CTNNB1HTR2AGAAMGLL | |
| SCHEMBL26374 | 0.86 | GAA (0.65) | BCL9CTNNB1HTR2AGAAMGLL | |
| SCHEMBL4744348 | 0.85 | HTR2A (0.57) | BCL9CTNNB1HTR2AGAAMGLL | |
| SCHEMBL12201077 | 0.84 | HTR2A (0.64) | BCL9CTNNB1HTR2AGAAMGLL | |
| Hydrochloric Acid SCHEMBL7895043 | 0.84 | GAA (0.62) | BCL9CTNNB1HTR2AGAAMGLL | |
| SCHEMBL47952 | 0.84 | RAB9A (0.56) | ALDH1A1LMNAKMT2ASMN1; SMN2NPC1 | |
| Ethylene Glycol SCHEMBL5476146 | 0.83 | BCL9 (0.58) | BCL9CTNNB1HTR2AGAAMGLL | |
| Acetic Acid SCHEMBL28965272 | 0.83 | GAA (0.62) | BCL9CTNNB1HTR2AGAAMGLL | |
| SCHEMBL4416673 | 0.83 | HSPB1 (0.59) | BCL9CTNNB1MAPTALDH1A1LMNA | |
| Bicarbonate SCHEMBL31202990 | 0.83 | MAPT (0.55) | BCL9CTNNB1GAAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9956293-B2 | Targeted therapeutics | MADRIGAL PHARMACEUTICALS, INC. (US) | 2018-05-01 | — | — | US | disclosed |
| US-20170128580-A1 | TARGETED THERAPEUTICS | TARVEDA THERAPEUTICS, INC. | 2017-05-11 | — | — | US | disclosed |
| US-9597343-B2 | Targeted therapeutics | SYNTA PHARMACEUTICALS CORP. (US) | 2017-03-21 | — | — | US | disclosed |
| US-20170056511-A1 | TARGETED THERAPEUTICS | LSI FINANCING LLC, AS ADMINISTRATIVE AGENT | 2017-03-02 | — | — | US | disclosed |
| US-20170056510-A1 | TARGETED THERAPEUTICS | SYNTA PHARMACEUTICALS CORP. (US) | 2017-03-02 | — | — | US | disclosed |
| US-20170049899-A1 | TARGETED THERAPEUTICS | LSI FINANCING LLC, AS ADMINISTRATIVE AGENT | 2017-02-23 | — | — | US | disclosed |
| US-20150139905-A1 | TARGETED THERAPEUTICS | MADRIGAL PHARMACEUTICALS, INC. | 2015-05-21 | — | — | US | disclosed |
| US-20140079636-A1 | TARGETED THERAPEUTICS | SYNTA PHARMACEUTICALS CORP. | 2014-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170128580-A1 | TARGETED THERAPEUTICS | CDC37, HSP90AB1, HSP90B1 | BCL9 1131/4885CTNNB1 3817/4885HTR2A 3907/4885 |
| US-20150139905-A1 | TARGETED THERAPEUTICS | CDC37, HSP90AB1, HSP90B1 | BCL9 1131/4885CTNNB1 3817/4885HTR2A 3907/4885 |
| US-20170049899-A1 | TARGETED THERAPEUTICS | CDC37, HSP90AB1, HSP90B1 | BCL9 1131/4885CTNNB1 3817/4885HTR2A 3907/4885 |
| US-20170056511-A1 | TARGETED THERAPEUTICS | CDC37, HSP90AB1, HSP90B1 | BCL9 1131/4885CTNNB1 3817/4885HTR2A 3907/4885 |
| US-20170056510-A1 | TARGETED THERAPEUTICS | CDC37, HSP90AB1, HSP90B1 | BCL9 1131/4885CTNNB1 3817/4885HTR2A 3907/4885 |
| US-20140079636-A1 | TARGETED THERAPEUTICS | CDC37, HSP90AB1, HSP90B1 | BCL9 1129/4885CTNNB1 3804/4885HTR2A 3910/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.