Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | GMNN | O75496 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TTR | P02766 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | DHODH | Q02127 | 1/20 | 0.51 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15615888 | 0.89 | LMNA (0.53) | ALDH1A1LMNAMTORSYKTP53 | |
| SCHEMBL15615882 | 0.86 | MAPT (0.52) | ALDH1A1PKMAURKATP53MAPT | |
| SCHEMBL14978436 | 0.84 | CTSC (0.44) | ALDH1A1LMNAMTORAURKAEGFR | |
| SCHEMBL17031567 | 0.84 | EGFR (0.49) | MEN1KMT2AALDH1A1NFKB1AURKA | |
| SCHEMBL16804753 | 0.82 | MTOR (0.43) | MTOREGFRCTSCTP53MAPT | |
| SCHEMBL15615969 | 0.80 | CNR2 (0.58) | CYP1A2CYP3A4CYP2C9AKR1C3AKR1C2 | |
| SCHEMBL28821019 | 0.80 | CTSC (0.45) | MTOREGFRCTSCTP53MAPT | |
| SCHEMBL16086165 | 0.78 | IDH2 (0.44) | MTOREGFRCTSCTP53MAPT | |
| SCHEMBL27930761 | 0.76 | MTOR (0.39) | MEN1KMT2AALDH1A1LMNAMTOR | |
| SCHEMBL11541557 | 0.74 | MPO (0.63) | MPOMEN1KMT2AGMNNALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2896622-B1 | PI3K AND/OR MTOR INHIBITOR | XUANZHU PHARMA CO LTD (CN) | 2017-05-03 | — | — | EP | disclosed |
| EP-2896622-B1 | PI3K AND/OR MTOR INHIBITOR | XUANZHU PHARMA CO LTD (CN) | 2017-05-03 | — | — | EP | disclosed |
| US-9365572-B2 | PI3K and/or mTOR inhibitor | Xuanzhu Pharma Co., Ltd. (CN) | 2016-06-14 | — | — | US | disclosed |
| US-9365572-B2 | PI3K and/or mTOR inhibitor | Xuanzhu Pharma Co., Ltd. (CN) | 2016-06-14 | — | — | US | disclosed |
| US-20150239885-A1 | PI3K AND/OR MTOR INHIBITOR | Xuanzhu Pharma Co., Ltd. (CN) | 2015-08-27 | — | — | US | disclosed |
| US-20150239885-A1 | PI3K AND/OR MTOR INHIBITOR | Xuanzhu Pharma Co., Ltd. (CN) | 2015-08-27 | — | — | US | disclosed |
| EP-2896622-A1 | PI3K AND/OR MTOR INHIBITOR | Xuanzhu Pharma Co., Ltd. (CN) | 2015-07-22 | — | — | EP | disclosed |
| WO-2014154026-A1 | PI3K AND/OR mTOR INHIBITOR PRODRUG | 山东轩竹医药科技有限公司 (CN) | 2014-10-02 | — | — | WO | disclosed |
| WO-2014040373-A1 | PI3K AND/OR MTOR INHIBITOR | 山东轩竹医药科技有限公司 (CN) | 2014-03-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150239885-A1 | PI3K AND/OR MTOR INHIBITOR | MTOR, RICTOR, RPTOR | MPO 4003/4885MEN1 857/4885KMT2A 2585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.