Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | MELK | Q14680 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17031568 | 0.86 | AURKB (0.57) | GAAAURKAAURKBALDH1A1CREBBP | |
| SCHEMBL15615876 | 0.84 | MPO (0.51) | EGFRMAPK8AURKAAKR1C3AKR1C2 | |
| SCHEMBL17031570 | 0.80 | CNR2 (0.53) | CSF1RALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL17134561 | 0.79 | EGFR (0.49) | EGFRCSF1RERBB2MAPK8AURKA | |
| SCHEMBL10251065 | 0.76 | AKR1C3 (0.51) | GAAMAPK8AURKAAURKBAKR1C3 | |
| SCHEMBL15615888 | 0.75 | LMNA (0.53) | PDE4BALDH1A1 | |
| SCHEMBL15615882 | 0.74 | MAPT (0.52) | AURKAAURKBALDH1A1CREBBPKDM4E | |
| SCHEMBL17134773 | 0.74 | CSF1R (0.45) | EGFRCSF1RMAPK8AURKAAURKB | |
| SCHEMBL4716452 | 0.74 | EGFR (0.56) | EGFRMAPK8AURKAAURKBAKR1C3 | |
| SCHEMBL16337913 | 0.72 | MELK (0.77) | MELK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9365572-B2 | PI3K and/or mTOR inhibitor | Xuanzhu Pharma Co., Ltd. (CN) | 2016-06-14 | — | — | US | disclosed |
| US-20150239885-A1 | PI3K AND/OR MTOR INHIBITOR | Xuanzhu Pharma Co., Ltd. (CN) | 2015-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150239885-A1 | PI3K AND/OR MTOR INHIBITOR | MTOR, RICTOR, RPTOR | EGFR 499/4885CSF1R 1324/4885ERBB2 387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.