Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 13/20 | 0.47 |
| ▸ | MMP13 | P45452 | 13/20 | 0.47 |
| ▸ | MMP1 | P03956 | 11/20 | 0.47 |
| ▸ | MMP2 | P08253 | 11/20 | 0.47 |
| ▸ | MMP7 | P09237 | 9/20 | 0.47 |
| ▸ | MMP3 | P08254 | 9/20 | 0.47 |
| ▸ | MMP8 | P22894 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.45 |
| ▸ | MMP14 | P50281 | 2/20 | 0.45 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.45 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.45 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12467075 | 0.86 | MMP2 (0.56) | MMP9MMP13MMP1MMP2MMP7 | |
| SCHEMBL159724 | 0.81 | CYP2C9 (0.50) | MMP9MMP13MMP1MMP2MMP7 | |
| SCHEMBL255126 | 0.81 | MMP2 (0.67) | MMP9MMP13MMP1MMP2MMP7 | |
| SCHEMBL15235738 | 0.77 | MMP9 (0.49) | MMP9MMP13MMP1MMP2MMP7 | |
| SCHEMBL15515020 | 0.77 | MMP9 (0.58) | MMP9MMP13MMP1MMP2MMP7 | |
| SCHEMBL15235737 | 0.76 | MMP9 (0.50) | MMP9MMP13MMP1MMP2MMP7 | |
| SCHEMBL6723663 | 0.76 | MMP9 (0.72) | MMP9MMP13MMP1MMP2MMP7 | |
| SCHEMBL690201 | 0.76 | MMP2 (0.68) | MMP9MMP13MMP1MMP2MMP7 | |
| SCHEMBL690202 | 0.76 | MMP2 (0.68) | MMP9MMP13MMP1MMP2MMP7 | |
| SCHEMBL6723666 | 0.76 | MMP9 (0.72) | MMP9MMP13MMP1MMP2MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170349544-A1 | Ethynylbenzene Derivatives | DUKE UNIVERSITY | 2017-12-07 | — | — | US | disclosed |
| US-20170349544-A1 | Ethynylbenzene Derivatives | DUKE UNIVERSITY | 2017-12-07 | — | — | US | disclosed |
| US-9738604-B2 | Ethynylbenzene derivatives | DUKE UNIVERSITY (US) | 2017-08-22 | — | — | US | disclosed |
| US-9738604-B2 | Ethynylbenzene derivatives | DUKE UNIVERSITY (US) | 2017-08-22 | — | — | US | disclosed |
| US-20130231323-A1 | ETHYNYLBENZENE DERIVATIVES | DUKE UNIVERSITY (US) | 2013-09-05 | — | — | US | disclosed |
| US-20130231323-A1 | ETHYNYLBENZENE DERIVATIVES | DUKE UNIVERSITY (US) | 2013-09-05 | — | — | US | disclosed |
| WO-2012031298-A2 | ETHYNYLBENZENE DERIVATIVES | DUKE UNIVERSITY (US) | 2012-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170349544-A1 | Ethynylbenzene Derivatives | Q6ZSR9, EPX, ZYX | MMP9 3060/4885MMP13 2833/4885MMP1 3600/4885 |
| US-20130231323-A1 | ETHYNYLBENZENE DERIVATIVES | Q6ZSR9, EPX, ZYX | MMP9 3060/4885MMP13 2833/4885MMP1 3600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.