⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15618330 | 0.73 | EPHX1 (0.31) | — | |
| SCHEMBL22624887 | 0.69 | — | — | |
| SCHEMBL8070359 | 0.69 | ALDH1A1 (0.34) | — | |
| Hydrochloric Acid SCHEMBL15618485 | 0.64 | LMNA (0.31) | — | |
| SCHEMBL16186181 | 0.63 | L3MBTL1 (0.31) | — | |
| SCHEMBL3657894 | 0.62 | — | — | |
| SCHEMBL2869108 | 0.60 | — | — | |
| SCHEMBL15526765 | 0.60 | — | — | |
| SCHEMBL2705365 | 0.60 | — | — | |
| SCHEMBL14152184 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897939-B1 | BENZOIMIDAZOLE-CARBOXYLIC ACID AMIDE DERIVATIVES FOR TREATING METABOLIC OR CARDIOVASCULAR DISEASES | SANOFI SA (FR) | 2017-02-01 | — | — | EP | disclosed |
| US-9156796-B2 | Benzoimidazole-carboxylic acid amide derivatives as APJ receptor modulators | SANOFI (FR) | 2015-10-13 | — | — | US | disclosed |
| EP-2897939-A1 | BENZOIMIDAZOLE-CARBOXYLIC ACID AMIDE DERIVATIVES AS APJ RECEPTOR MODULATORS | SANOFI (FR) | 2015-07-29 | — | — | EP | disclosed |
| WO-2014044738-A1 | BENZOIMIDAZOLE-CARBOXYLIC ACID AMIDE DERIVATIVES AS APJ RECEPTOR MODULATORS | SANOFI (FR) | 2014-03-27 | — | — | WO | disclosed |