SCHEMBL156196

SCHEMBL156196

CC1Nc2[nH]c(N)nc(=O)c2NC1C

nearest known ligand 0.35

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.35
ALDH1A1 P00352 1/20 0.35
LMNA P02545 1/20 0.35
HPGD P15428 1/20 0.35
NOS1 P29475 5/20 0.31
NOS3 P29474 1/20 0.31
NOS2 P35228 1/20 0.31
PNP P00491 1/20 0.31
CYP3A4 P08684 1/20 0.31
BLM P54132 1/20 0.31
USP2 O75604 1/20 0.30
CASP7 P55210 1/20 0.30
HSD17B10 Q99714 1/20 0.30
PAH P00439 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL625930 0.98 ALDH1A1 (0.37) KDM4EALDH1A1LMNAHPGDNOS1
Hydrochloric Acid SCHEMBL28835504 0.96 KDM4E (0.33) KDM4EALDH1A1LMNAHPGDNOS1
Hydrochloric Acid SCHEMBL16741182 0.75 KDM4E (0.36) KDM4EALDH1A1HPGDNOS1NOS3
SCHEMBL156195 0.70 KDM4E (0.57) KDM4EALDH1A1LMNAHPGDNOS1
Hydrochloric Acid SCHEMBL625929 0.69 KDM4E (0.59) KDM4EALDH1A1LMNAHPGDNOS1
SCHEMBL9054708 0.66
Sapropterin SCHEMBL37480 0.66 NOS1 (0.65) KDM4EALDH1A1LMNAHPGDNOS1
Sapropterin SCHEMBL258544 0.66 NOS1 (0.65) KDM4EALDH1A1LMNAHPGDNOS1
Sapropterin SCHEMBL31673726 0.66 NOS1 (0.65) KDM4EALDH1A1LMNAHPGDNOS1
Sapropterin SCHEMBL1534380 0.66 NOS1 (0.65) KDM4EALDH1A1LMNAHPGDNOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 551 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9663804-B2 Method of treating polyester textile NOVOZYMES A/S (DK) 2017-05-30 US claimed
US-20130183722-A1 Compositions Comprising A Polypeptide Having Cellulolytic Enhancing Activity And A Nitrogen-Contaning Compound And Uses Thereof NOVOZYMES, INC. (US) 2013-07-18 US claimed
EP-2603593-A1 COMPOSITIONS COMPRISING A POLYPEPTIDE HAVING CELLULOLYTIC ENHANCING ACTIVITY AND A NITROGEN-CONTAINING COMPOUND AND USES THEREOF Novozymes, Inc. (US) 2013-06-19 EP claimed
WO-2012021399-A1 COMPOSITIONS COMPRISING A POLYPEPTIDE HAVING CELLULOLYTIC ENHANCING ACTIVITY AND A NITROGEN-CONTAINING COMPOUND AND USES THEREOF NOVOZYMES, INC. (US) 2012-02-16 WO claimed
US-12600996-B2 Carbohydrate binding module variants and hybrid polypeptides comprising same NOVOZYMES A/S (DK) 2026-04-14 US disclosed
US-20250092434-A1 CELLULOLYTIC ENZYME COMPOSITIONS AND USES THEREOF NOVOZYMES, INC. (US) 2025-03-20 US disclosed
US-12195776-B2 Cellulolytic enzyme compositions and uses thereof NOVOZYMES, INC. (US) 2025-01-14 US disclosed
US-20240376507-A9 CELLULOLYTIC ENZYME COMPOSITIONS AND USES THEREOF NOVOZYMES, INC. (US) 2024-11-14 US disclosed
EP-4458964-A2 CELLOBIOHYDROLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME Novozymes A/S (DK) 2024-11-06 EP disclosed
EP-3586610-B1 POLYPEPTIDES HAVING CELLULOLYTIC ENHANCING ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME NOVOZYMES AS (DK) 2024-09-25 EP disclosed
EP-3739045-B1 CELLOBIOHYDROLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME NOVOZYMES AS (DK) 2024-08-14 EP disclosed
EP-4406964-A2 CARBOHYDRATE BINDING MODULE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME Novozymes A/S (DK) 2024-07-31 EP disclosed
EP-1216246-A1 N-SUBSTITUTED 4-AMINOPTERIDINES, SYNTHESIS AND USE THEREOF AS PHARMACEUTICAL AGENT Vasopharm Biotech GmbH & Co. KG (DE) 2002-06-26 EP disclosed
WO-2001021619-A1 N-SUBSTITUTED 4-AMINOPTERIDINES, SYNTHESIS AND USE THEREOF AS PHARMACEUTICAL AGENT VASOPHARM BIOTECH GMBH & CO. KG (DE) 2001-03-29 WO disclosed
US-5401844-A Chemical intermediates for treatment of parkinson*s disease SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION (US) 1995-03-28 US disclosed
US-5196533-A Treatment of Parkinson*s disease, inhibitor of thymidylate synthetase SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION, USA (US) 1993-03-23 US disclosed
EP-0138995-B1 REGULATION OF ENZYMES WHICH UTILIZE TETRAHYDROBIOPTERIN OR TETRAHYDROFOLATE COFACTORS WITH 6, 6-DISUBSTITUTED-TETRAHYDROPTERIDINES South Alabama Medical Science Foundation (US) 1991-08-14 EP disclosed
EP-0138995-A4 REGULATION OF ENZYMES WHICH UTILIZE TETRAHYDROBIOPTERIN OR TETRAHYDROFOLATE COFACTORS WITH 6, 6-DISUBSTITUTED-TETRAHYDROPTERIDINES. UNIV SOUTH ALABAMA (US) 1988-05-10 EP disclosed
EP-0138995-A1 REGULATION OF ENZYMES WHICH UTILIZE TETRAHYDROBIOPTERIN OR TETRAHYDROFOLATE COFACTORS WITH 6, 6-DISUBSTITUTED-TETRAHYDROPTERIDINES. UNIV SOUTH ALABAMA (US) 1985-05-02 EP disclosed
WO-1984004040-A1 REGULATION OF ENZYMES WHICH UTILIZE TETRAHYDROBIOPTERIN OR TETRAHYDROFOLATE COFACTORS WITH 6, 6-DISUBSTITUTED-TETRAHYDROPTERIDINES UNIV SOUTH ALABAMA (US) 1984-10-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12600996-B2 Carbohydrate binding module variants and hybrid polypeptides comprising same QPCTL, DNTT, RNGTT KDM4E 1976/4885ALDH1A1 4658/4885LMNA 3634/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.