Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | ODC1 | P11926 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.38 |
| ▸ | TOP1 | P11387 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6189538 | 0.78 | ALDH1A1 (0.39) | SMN1; SMN2CA1CA2CA7CA9 | |
| SCHEMBL8800959 | 0.76 | TOP1 (0.40) | SMN1; SMN2CA1CA2CA7CA9 | |
| SCHEMBL11858211 | 0.75 | P2RX7 (0.43) | SMN1; SMN2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL10634123 | 0.74 | ACHE (0.42) | SMN1; SMN2CA1CA2CA9CA12 | |
| SCHEMBL8908078 | 0.73 | CA1 (0.41) | SMN1; SMN2CA1CA2CA7CA9 | |
| SCHEMBL4024400 | 0.73 | IDO1 (0.40) | SMN1; SMN2CA1CA2CA7CA9 | |
| SCHEMBL8800389 | 0.73 | CA12 (0.44) | SMN1; SMN2CA1CA2CA7CA9 | |
| Bromide SCHEMBL1307432 | 0.73 | SMN1; SMN2 (0.56) | SMN1; SMN2CA1CA2CA7CA9 | |
| SCHEMBL25434306 | 0.72 | CA1 (0.61) | SMN1; SMN2CA1CA2CA7CA9 | |
| SCHEMBL151213 | 0.72 | CA1 (0.61) | SMN1; SMN2CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014047447-A2 | FTO MODULATING COMPOUNDS AND METHODS OF USE | MIDWESTERN UNIVERSITY (US) | 2014-03-27 | — | — | WO | disclosed |