Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | CCR8 | P51685 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1207404 | 0.81 | SYK (0.53) | L3MBTL1FFAR1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL27912151 | 0.80 | KDM4E (0.54) | L3MBTL1FFAR1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL23039389 | 0.79 | L3MBTL1 (0.44) | L3MBTL1SMN1; SMN2KDM4EMAPTALDH1A1 | |
| SCHEMBL30895181 | 0.79 | L3MBTL1 (0.44) | L3MBTL1SMN1; SMN2KDM4EMAPTALDH1A1 | |
| SCHEMBL26260082 | 0.79 | LMNA (0.48) | L3MBTL1SMN1; SMN2KDM4ELMNAHTT | |
| SCHEMBL5462166 | 0.78 | SMN1; SMN2 (0.55) | L3MBTL1FFAR1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL9815139 | 0.75 | ALDH1A1 (0.58) | L3MBTL1SMN1; SMN2KDM4ELMNAMAPT | |
| SCHEMBL28004817 | 0.75 | ERN1 (0.51) | L3MBTL1SMN1; SMN2KDM4EMAPTALDH1A1 | |
| SCHEMBL15618043 | 0.72 | APLNR (0.55) | L3MBTL1FFAR1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL28180497 | 0.72 | KDM4E (0.54) | L3MBTL1FFAR1SMN1; SMN2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424843-B1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES | NOVARTIS AG (CH) | 2014-03-26 | — | — | EP | disclosed |