Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NCF1 | P14598 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29852012 | 1.00 | MAPT (0.43) | MAPTTP53NPC1RAB9APTK2B | |
| SCHEMBL19389245 | 0.89 | MAPT (0.37) | MAPTTP53NPC1RAB9APTK2B | |
| SCHEMBL30658791 | 0.84 | MAPT (0.45) | MAPTTP53NPC1RAB9APTK2B | |
| SCHEMBL15619940 | 0.84 | MAPT (0.45) | MAPTTP53NPC1RAB9APTK2B | |
| SCHEMBL29852185 | 0.83 | KMT2A (0.40) | MAPTKMT2ACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL15627560 | 0.83 | KMT2A (0.40) | MAPTKMT2ACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL19620504 | 0.80 | TP53 (0.43) | MAPTTP53NPC1RAB9APTK2B | |
| SCHEMBL29851977 | 0.79 | KMT2A (0.40) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL19620557 | 0.79 | KMT2A (0.40) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL15627563 | 0.79 | KMT2A (0.40) | MAPTNPC1RAB9ASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897607-B1 | INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER | RHODE ISLAND HOSPITAL (US) | 2017-11-22 | — | — | EP | claimed |
| US-20220251076-A1 | Inhibitors of Beta-Hydoxylase for Treatment of Cancer | MIDWESTERN UNIVERSITY | 2022-08-11 | — | — | US | disclosed |
| US-20220251076-A1 | Inhibitors of Beta-Hydoxylase for Treatment of Cancer | MIDWESTERN UNIVERSITY | 2022-08-11 | — | — | US | disclosed |
| US-20210052561-A1 | TARGETING ASPARTATE BETA-HYDROXYLASE SUPPRESSES TUMOR MALIGNANCY AND METASTASIS | MIDWESTERN UNIVERSITY | 2021-02-25 | — | — | US | disclosed |
| US-20210052561-A1 | TARGETING ASPARTATE BETA-HYDROXYLASE SUPPRESSES TUMOR MALIGNANCY AND METASTASIS | MIDWESTERN UNIVERSITY | 2021-02-25 | — | — | US | disclosed |
| US-20210032233-A1 | Inhibitors of Beta-Hydroxylase for Treatment of Cancer | MIDWESTERN UNIVERSITY | 2021-02-04 | — | — | US | disclosed |
| US-20210032233-A1 | Inhibitors of Beta-Hydroxylase for Treatment of Cancer | MIDWESTERN UNIVERSITY | 2021-02-04 | — | — | US | disclosed |
| EP-3345596-B1 | INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER | RHODE ISLAND HOSPITAL (US) | 2021-01-20 | — | — | EP | disclosed |
| EP-3345596-B1 | INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER | RHODE ISLAND HOSPITAL (US) | 2021-01-20 | — | — | EP | disclosed |
| US-20200361925-A1 | INHIBITORS OF BETA-HYDROXYLASE FOR TREATMENT OF CANCER | RHODE ISLAND HOSPITAL (US) | 2020-11-19 | — | — | US | disclosed |
| US-20180009798-A1 | Inhibitors of Beta-Hydroxylase for Treatment of Cancer | MIDWESTERN UNIVERSITY | 2018-01-11 | — | — | US | disclosed |
| EP-2897607-B1 | INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER | RHODE ISLAND HOSPITAL (US) | 2017-11-22 | — | — | EP | disclosed |
| EP-2897607-B1 | INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER | RHODE ISLAND HOSPITAL (US) | 2017-11-22 | — | — | EP | disclosed |
| US-9771356-B2 | Inhibitors of beta-hydroxylase for treatment of cancer | RHODE ISLAND HOSPITAL (US) | 2017-09-26 | — | — | US | disclosed |
| US-9771356-B2 | Inhibitors of beta-hydroxylase for treatment of cancer | RHODE ISLAND HOSPITAL (US) | 2017-09-26 | — | — | US | disclosed |
| US-9771356-B2 | Inhibitors of beta-hydroxylase for treatment of cancer | RHODE ISLAND HOSPITAL (US) | 2017-09-26 | — | — | US | disclosed |
| US-20150210677-A1 | Inhibitors of Beta-Hydroxylase for Treatment of Cancer | MIDWESTERN UNIVERSITY | 2015-07-30 | — | — | US | disclosed |
| US-20150210677-A1 | Inhibitors of Beta-Hydroxylase for Treatment of Cancer | MIDWESTERN UNIVERSITY | 2015-07-30 | — | — | US | disclosed |
| US-20150210677-A1 | Inhibitors of Beta-Hydroxylase for Treatment of Cancer | MIDWESTERN UNIVERSITY | 2015-07-30 | — | — | US | disclosed |
| WO-2014047519-A2 | INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER | RHODE ISLAND HOSPITAL (US) | 2014-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210032233-A1 | Inhibitors of Beta-Hydroxylase for Treatment of Cancer | ASPH, CYP46A1, ALDH7A1 | MAPT 3252/4885TP53 873/4885NPC1 1175/4885 |
| US-20210052561-A1 | TARGETING ASPARTATE BETA-HYDROXYLASE SUPPRESSES TUMOR MALIGNANCY AND METASTASIS | ASPH, GOT1, FOLH1 | MAPT 2280/4885TP53 292/4885NPC1 529/4885 |
| US-20220251076-A1 | Inhibitors of Beta-Hydoxylase for Treatment of Cancer | ASPH, HAGH, FAH | MAPT 3925/4885TP53 717/4885NPC1 934/4885 |
| US-20200361925-A1 | INHIBITORS OF BETA-HYDROXYLASE FOR TREATMENT OF CANCER | ASPH, CYP46A1, ALDH7A1 | MAPT 3252/4885TP53 873/4885NPC1 1175/4885 |
| US-20180009798-A1 | Inhibitors of Beta-Hydroxylase for Treatment of Cancer | ASPH, CYP46A1, ALDH7A1 | MAPT 3252/4885TP53 873/4885NPC1 1175/4885 |
| US-20150210677-A1 | Inhibitors of Beta-Hydroxylase for Treatment of Cancer | ASPH, ALDH7A1, ARNT | MAPT 2900/4885TP53 745/4885NPC1 1458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.