Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4562599 | 0.98 | SMN1; SMN2 (0.40) | SMN1; SMN2NPC1RAB9AL3MBTL1ALPL | |
| SCHEMBL15627195 | 0.86 | SMN1; SMN2 (0.41) | SMN1; SMN2NPC1RAB9AL3MBTL1ALPL | |
| SCHEMBL17279724 | 0.82 | NR1H2 (0.59) | SMN1; SMN2NPC1RAB9AL3MBTL1ALPL | |
| SCHEMBL22638176 | 0.75 | KDM4E (0.43) | SMN1; SMN2NPC1RAB9AALPLHSD17B10 | |
| SCHEMBL66901 | 0.72 | HPGDS (0.48) | SMN1; SMN2NPC1RAB9APKMHSD17B10 | |
| SCHEMBL100765 | 0.65 | HPGDS (0.46) | HPGDSLTA4H | |
| SCHEMBL6449793 | 0.64 | ADORA2A (0.69) | SMN1; SMN2NPC1RAB9AL3MBTL1ALPL | |
| SCHEMBL27514396 | 0.63 | METAP1 (0.55) | — | |
| SCHEMBL12283320 | 0.63 | GAA (0.37) | SMN1; SMN2NPC1RAB9AL3MBTL1ALPL | |
| SCHEMBL2348095 | 0.63 | HPGDS (0.33) | HPGDSLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170112845-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2017-04-27 | — | — | US | disclosed |
| US-20150250795-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2015-09-10 | — | — | US | disclosed |
| US-9061030-B2 | sGC stimulators | IRONWOOD PHARMACEUTICALS, INC. (US) | 2015-06-23 | — | — | US | disclosed |
| US-20140088071-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2014-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150250795-A1 | sGC STIMULATORS | PTGIS, GUCY1B1, GUCY1A1 | SMN1; SMN2 1499/4885NPC1 2967/4885RAB9A 2039/4885 |
| US-20140088071-A1 | sGC STIMULATORS | PTGIS, GUCY1B1, GUCY1A1 | SMN1; SMN2 1279/4885NPC1 3154/4885RAB9A 2122/4885 |
| US-20170112845-A1 | sGC STIMULATORS | PTGIS, GUCY1B1, GUCY1A1 | SMN1; SMN2 1499/4885NPC1 2967/4885RAB9A 2039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.