Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14172986 | 0.89 | CTSL (0.46) | CTSLSLC5A2ALDH1A1MAPTTRPA1 | |
| SCHEMBL16519839 | 0.84 | SLC5A2 (0.42) | SLC5A2HTTALDH1A1MAPTPTGS1 | |
| SCHEMBL16499627 | 0.82 | SLC5A2 (0.44) | CTSLSLC5A2MAPTPTGS1PTGS2 | |
| SCHEMBL31726624 | 0.82 | SLC5A2 (0.44) | CTSLSLC5A2MAPTPTGS1PTGS2 | |
| SCHEMBL9838345 | 0.77 | AKR1B1 (0.48) | SLC5A2GAAALDH1A1MAPTTSHR | |
| SCHEMBL11339018 | 0.76 | ALDH1A1 (0.38) | CTSLGAAALDH1A1MAPTTSHR | |
| SCHEMBL12108116 | 0.75 | CTSL (0.42) | CTSLNPC1RAB9AHTTSMN1; SMN2 | |
| SCHEMBL20382503 | 0.75 | SLC5A2 (0.34) | SLC5A2PTGS1PTGS2SLC6A4 | |
| SCHEMBL442330 | 0.74 | NPC1 (0.53) | NPC1RAB9AGAAHTTSMN1; SMN2 | |
| SCHEMBL30361595 | 0.74 | NPC1 (0.53) | NPC1RAB9AGAAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160222047-A1 | C-ARYL GLUCOSIDE DERIVATIVE, PREPARATION METHODS THEREOF, AND MEDICAL APPLICATIONS THEREOF | JIANGSU HANSOH PHARMACEUTICAL CO., LTD. (CN) | 2016-08-04 | — | — | US | disclosed |
| US-9034921-B2 | Diphenylmethane derivatives as SGLT2 inhibitors | GREEN CROSS CORPORATION (KR) | 2015-05-19 | — | — | US | disclosed |
| US-20140088079-A1 | NOVEL DIPHENYLMETHANE DERIVATIVES AS SGLT2 INHIBITORS | GREEN CROSS CORPORATION (KR) | 2014-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140088079-A1 | NOVEL DIPHENYLMETHANE DERIVATIVES AS SGLT2 INHIBITORS | SLC5A2, SLC5A1, SLC2A8 | CTSL 4497/4885SLC5A2 1/4885NPC1 265/4885 |
| US-20160222047-A1 | C-ARYL GLUCOSIDE DERIVATIVE, PREPARATION METHODS THEREOF, AND MEDICAL APPLICATIONS THEREOF | SLC5A1, SLC5A2, UGGT1 | CTSL 1017/4885SLC5A2 2/4885NPC1 158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.