Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 4/20 | 0.48 |
| ▸ | RXRB | P28702 | 3/20 | 0.43 |
| ▸ | RXRA | P19793 | 2/20 | 0.43 |
| ▸ | RXRG | P48443 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | RGS12 | O14924 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1861656 | 0.90 | AKR1B1 (0.50) | AKR1B1RXRBRXRARXRGPOLB | |
| SCHEMBL16499627 | 0.80 | SLC5A2 (0.44) | MAPTHPGDHSD17B10LMNASLC5A2 | |
| SCHEMBL31726624 | 0.80 | SLC5A2 (0.44) | MAPTHPGDHSD17B10LMNASLC5A2 | |
| SCHEMBL16519839 | 0.78 | SLC5A2 (0.42) | MAPTHPGDLMNAMEN1ALDH1A1 | |
| SCHEMBL3838996 | 0.78 | RXRB (0.62) | AKR1B1RXRBRXRARXRGPOLB | |
| SCHEMBL9548959 | 0.78 | AKR1B1 (0.51) | AKR1B1RXRBRXRARXRGPOLB | |
| SCHEMBL15629940 | 0.77 | CTSL (0.41) | POLBMAPTGAATSHRMEN1 | |
| SCHEMBL5527444 | 0.76 | RXRB (0.65) | AKR1B1RXRBRXRARXRGPOLB | |
| SCHEMBL19996854 | 0.76 | RXRB (0.60) | AKR1B1RXRBRXRARXRGPOLB | |
| SCHEMBL25569782 | 0.76 | AKR1B1 (0.36) | AKR1B1POLBMAPTHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11084784-B2 | ROR-gamma modulators and uses thereof | Piramal Enterprises Limited (IN) | 2021-08-10 | — | — | US | disclosed |
| US-20180215707-A1 | ROR-GAMMA MODULATORS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2018-08-02 | — | — | US | disclosed |
| EP-3122721-A1 | ROR-GAMMA MODULATORS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2017-02-01 | — | — | EP | disclosed |
| WO-2015145371-A1 | ROR-GAMMA MODULATORS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2015-10-01 | — | — | WO | disclosed |
| US-4994450-A | Side effect reduction | DR. LO. ZAMBELETTI S.P.A. (IT) | 1991-02-19 | — | — | US | disclosed |
| EP-0333315-A1 | Azacyclic compounds, processes for their preparation and their pharmaceutical use | Dr. Lo. Zambeletti S.p.A. (IT) | 1989-09-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11084784-B2 | ROR-gamma modulators and uses thereof | RORB, RORA, RORC | AKR1B1 317/4885RXRB 33/4885RXRA 50/4885 |
| US-20180215707-A1 | ROR-GAMMA MODULATORS AND USES THEREOF | RORB, RORA, RORC | AKR1B1 317/4885RXRB 33/4885RXRA 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.