Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.59 |
| ▸ | LATS1 | O95835 | 2/20 | 0.49 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.49 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15635354 | 0.84 | TBK1 (0.55) | TBK1LATS1LATS2CCNB2CDK1 | |
| SCHEMBL12501141 | 0.77 | IKBKE (0.58) | TBK1LATS1LATS2CCNB2CDK1 | |
| SCHEMBL12501028 | 0.76 | IKBKE (0.64) | TBK1LATS1LATS2TGFBR1IKBKE | |
| SCHEMBL12501125 | 0.76 | TGFBR1 (0.47) | TBK1LATS1LATS2CCNB2CDK1 | |
| SCHEMBL857640 | 0.74 | IMPDH2 (0.61) | LATS1LATS2CCNB2CDK1CCNB1 | |
| SCHEMBL12501059 | 0.74 | TBK1 (1.00) | TBK1LATS1LATS2TGFBR1IKBKE | |
| SCHEMBL858712 | 0.73 | LATS1 (0.50) | TBK1LATS1LATS2CCNB2CDK1 | |
| SCHEMBL12501053 | 0.72 | LATS1 (0.53) | TBK1LATS1LATS2CCNB2CDK1 | |
| SCHEMBL15397130 | 0.71 | GSK3B (0.48) | TBK1LATS1LATS2CCNB2CDK1 | |
| SCHEMBL23107328 | 0.70 | AURKA (0.46) | LATS1LATS2CCNB2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382244-B2 | 7-azaindole-2,7-naphthyridine derivative for the treatment of tumours | MERCK PATENT GMBH (DE) | 2016-07-05 | — | — | US | claimed |
| US-20150252041-A1 | 7-AZAINDOLE-2,7-NAPHTHYRIDINE DERIVATIVE FOR THE TREATMENT OF TUMOURS | MERCK PATENT GMBH (DE) | 2015-09-10 | — | — | US | claimed |
| EP-2903992-A1 | 7-AZAINDOL-2,7-NAPHTHYRIDINE DERIVATIVE FOR THE TREATMENT OF TUMORS | Merck Patent GmbH (DE) | 2015-08-12 | — | — | EP | claimed |
| WO-2014053208-A1 | 7-AZAINDOL-2,7-NAPHTHYRIDINE DERIVATIVE FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2014-04-10 | — | — | WO | claimed |
| US-9382244-B2 | 7-azaindole-2,7-naphthyridine derivative for the treatment of tumours | MERCK PATENT GMBH (DE) | 2016-07-05 | — | — | US | disclosed |
| US-9382244-B2 | 7-azaindole-2,7-naphthyridine derivative for the treatment of tumours | MERCK PATENT GMBH (DE) | 2016-07-05 | — | — | US | disclosed |
| US-9382244-B2 | 7-azaindole-2,7-naphthyridine derivative for the treatment of tumours | MERCK PATENT GMBH (DE) | 2016-07-05 | — | — | US | disclosed |
| US-9382244-B2 | 7-azaindole-2,7-naphthyridine derivative for the treatment of tumours | MERCK PATENT GMBH (DE) | 2016-07-05 | — | — | US | disclosed |
| US-20150252041-A1 | 7-AZAINDOLE-2,7-NAPHTHYRIDINE DERIVATIVE FOR THE TREATMENT OF TUMOURS | MERCK PATENT GMBH (DE) | 2015-09-10 | — | — | US | disclosed |
| US-20150252041-A1 | 7-AZAINDOLE-2,7-NAPHTHYRIDINE DERIVATIVE FOR THE TREATMENT OF TUMOURS | MERCK PATENT GMBH (DE) | 2015-09-10 | — | — | US | disclosed |
| US-20150252041-A1 | 7-AZAINDOLE-2,7-NAPHTHYRIDINE DERIVATIVE FOR THE TREATMENT OF TUMOURS | MERCK PATENT GMBH (DE) | 2015-09-10 | — | — | US | disclosed |
| US-20150252041-A1 | 7-AZAINDOLE-2,7-NAPHTHYRIDINE DERIVATIVE FOR THE TREATMENT OF TUMOURS | MERCK PATENT GMBH (DE) | 2015-09-10 | — | — | US | disclosed |
| EP-2903992-A1 | 7-AZAINDOL-2,7-NAPHTHYRIDINE DERIVATIVE FOR THE TREATMENT OF TUMORS | Merck Patent GmbH (DE) | 2015-08-12 | — | — | EP | disclosed |
| EP-2903992-A1 | 7-AZAINDOL-2,7-NAPHTHYRIDINE DERIVATIVE FOR THE TREATMENT OF TUMORS | Merck Patent GmbH (DE) | 2015-08-12 | — | — | EP | disclosed |
| WO-2014053208-A1 | 7-AZAINDOL-2,7-NAPHTHYRIDINE DERIVATIVE FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2014-04-10 | — | — | WO | disclosed |
| WO-2014053208-A1 | 7-AZAINDOL-2,7-NAPHTHYRIDINE DERIVATIVE FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2014-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150252041-A1 | 7-AZAINDOLE-2,7-NAPHTHYRIDINE DERIVATIVE FOR THE TREATMENT OF TUMOURS | MKI67, TK2, TYMP | TBK1 392/4885LATS1 129/4885LATS2 83/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.