Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.55 |
| ▸ | LATS1 | O95835 | 3/20 | 0.40 |
| ▸ | LATS2 | Q9NRM7 | 2/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | CLK3 | P49761 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15635164 | 0.84 | TBK1 (0.59) | TBK1LATS1LATS2TGFBR1PDPK1 | |
| SCHEMBL12501059 | 0.71 | TBK1 (1.00) | TBK1LATS1LATS2TGFBR1PDPK1 | |
| SCHEMBL14533462 | 0.69 | AURKA (0.44) | HTR6AURKAPARP1 | |
| SCHEMBL15635356 | 0.66 | LATS1 (0.40) | LATS1LATS2HTR6CLK1CLK2 | |
| SCHEMBL13572670 | 0.65 | GABRA1 (0.46) | TBK1PDPK1RETKDRAURKA | |
| SCHEMBL29955300 | 0.64 | KMT2A (0.44) | AURKAPARP1 | |
| SCHEMBL9285269 | 0.62 | AURKA (0.41) | AURKAPARP1 | |
| SCHEMBL12440236 | 0.62 | AXL (0.58) | TBK1CLK1CDK5DYRK1ACDK5R1 | |
| SCHEMBL17068258 | 0.62 | TBK1 (0.46) | TBK1HTR6CLK1DYRK1A | |
| SCHEMBL12501125 | 0.62 | TGFBR1 (0.47) | TBK1LATS1LATS2TGFBR1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903992-A1 | 7-AZAINDOL-2,7-NAPHTHYRIDINE DERIVATIVE FOR THE TREATMENT OF TUMORS | Merck Patent GmbH (DE) | 2015-08-12 | — | — | EP | disclosed |
| WO-2014053208-A1 | 7-AZAINDOL-2,7-NAPHTHYRIDINE DERIVATIVE FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2014-04-10 | — | — | WO | disclosed |