Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.35 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31636805 | 0.85 | L3MBTL1 (0.46) | ALDH1A1KDM4EL3MBTL1NPSR1 | |
| SCHEMBL3548766 | 0.81 | MAPT (0.38) | SORT1ALDH1A1KDM4EL3MBTL1NPSR1 | |
| SCHEMBL14771234 | 0.78 | NPSR1 (0.42) | KDM4EL3MBTL1NPSR1 | |
| SCHEMBL16240426 | 0.77 | CNR1 (0.43) | — | |
| Hydrochloric Acid SCHEMBL10710139 | 0.76 | MAOB (0.48) | KDM4EJAK2 | |
| SCHEMBL231248 | 0.75 | KMO (0.47) | SORT1ALDH1A1KDM4EL3MBTL1NPSR1 | |
| SCHEMBL31637017 | 0.75 | KMO (0.47) | SORT1ALDH1A1KDM4EL3MBTL1NPSR1 | |
| SCHEMBL2599594 | 0.75 | BRD4 (0.49) | ALDH1A1KDM4EL3MBTL1BRD4NPSR1 | |
| SCHEMBL10709764 | 0.75 | RAB9A (0.44) | — | |
| Lithium Ion SCHEMBL694807 | 0.74 | DHODH (0.34) | SORT1KDM4ESMARCA2SMARCA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9163021-B2 | Pyrrolo[3,2-c]pyridine tropomyosin-related kinase inhibitors | PFIZER LIMITED (GB) | 2015-10-20 | — | — | US | disclosed |
| US-20150246912-A1 | Pyrrolo[3,2-C]Pyridine Tropomyosin-Related Kinase Inhibitors | PFIZER LIMITED (GB) | 2015-09-03 | — | — | US | disclosed |
| EP-2912036-A1 | PYRROLO[3,2-C]PYRIDINE TROPOMYOSIN-RELATED KINASE INHIBITORS | Pfizer Limited (GB) | 2015-09-02 | — | — | EP | disclosed |
| WO-2014053968-A1 | PYRROLO[3,2-C]PYRIDINE TROPOMYOSIN-RELATED KINASE INHIBITORS | PFIZER LIMITED (GB) | 2014-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150246912-A1 | Pyrrolo[3,2-C]Pyridine Tropomyosin-Related Kinase Inhibitors | MUSK, TPM3, DMPK | PTGS2 2946/4885SORT1 4539/4885ALDH1A1 3219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.