Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.46 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.44 |
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | CDK9 | P50750 | 2/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 6/20 | 0.43 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | HTR7 | P34969 | 4/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15647363 | 0.90 | EGFR (0.45) | EGFRCDK5CDK5R1MAP3K11CCNT1 | |
| SCHEMBL29613438 | 0.89 | EGFR (0.51) | EGFRCDK5CDK5R1CCNT1CDK1 | |
| SCHEMBL16665592 | 0.89 | EGFR (0.51) | EGFRCDK5CDK5R1CCNT1CDK1 | |
| SCHEMBL15648288 | 0.88 | CDK1 (0.43) | CCNT1CDK1CCNB1CDK2CDK9 | |
| SCHEMBL15649053 | 0.87 | CDK7 (0.55) | EGFRCDK5CDK5R1MAP3K11CCNT1 | |
| SCHEMBL29613463 | 0.87 | CDK7 (0.55) | EGFRCDK5CDK5R1MAP3K11CCNT1 | |
| SCHEMBL17141040 | 0.85 | CDK7 (0.48) | EGFRCDK5CDK5R1MAP3K11CCNT1 | |
| SCHEMBL29613470 | 0.83 | EGFR (0.48) | EGFRCDK5CDK5R1CCNT1CDK1 | |
| SCHEMBL27223018 | 0.83 | EGFR (0.48) | EGFRCDK5CDK5R1CCNT1CDK1 | |
| SCHEMBL15648207 | 0.82 | EGFR (0.49) | EGFRCDK5CDK5R1MAP3K11CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10787436-B2 | Inhibitors of cyclin-dependent kinase 7 (CDK7) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-09-29 | — | — | US | disclosed |
| US-10787436-B2 | Inhibitors of cyclin-dependent kinase 7 (CDK7) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-09-29 | — | — | US | disclosed |
| US-20190100511-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-04-04 | — | — | US | disclosed |
| US-20190100511-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-04-04 | — | — | US | disclosed |
| US-10112927-B2 | Inhibitors of cyclin-dependent kinase 7 (CDK7) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-10-30 | — | — | US | disclosed |
| US-20160122323-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2016-05-05 | — | — | US | disclosed |
| EP-2909194-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | Dana-Farber Cancer Institute, Inc. (US) | 2015-08-26 | — | — | EP | disclosed |
| WO-2014063068-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2014-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190100511-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | CDK7, CDK9, CDK6 | EGFR 1051/4885CDK5 6/4885CDK5R1 33/4885 |
| US-20160122323-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | CDK7, CDK9, CDK6 | EGFR 1051/4885CDK5 6/4885CDK5R1 33/4885 |
| US-10112927-B2 | Inhibitors of cyclin-dependent kinase 7 (CDK7) | CDK7, CDK9, CDK6 | EGFR 1051/4885CDK5 6/4885CDK5R1 33/4885 |
| US-10787436-B2 | Inhibitors of cyclin-dependent kinase 7 (CDK7) | CDK7, CDK9, CDK6 | EGFR 1051/4885CDK5 6/4885CDK5R1 33/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.