Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HNF4A | P41235 | 1/20 | 0.47 |
| ▸ | MYC | P01106 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.41 |
| ▸ | BRS3 | P32247 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8420159 | 0.85 | HNF4A (0.63) | POLBKMT2AHNF4AMYCAKR1C3 | |
| SCHEMBL31402608 | 0.82 | KMT2A (0.60) | GAANPC1RAB9AKMT2AHNF4A | |
| SCHEMBL372 | 0.82 | KMT2A (0.60) | GAANPC1RAB9AKMT2AHNF4A | |
| SCHEMBL11142513 | 0.81 | POLB (0.54) | POLBGAANPC1RAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL7610390 | 0.80 | KMT2A (0.59) | GAANPC1RAB9AKMT2AHNF4A | |
| SCHEMBL17965677 | 0.79 | TSHR (0.52) | POLBGAANPC1RAB9AKMT2A | |
| SCHEMBL12285691 | 0.79 | ACHE (0.40) | POLBNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL867477 | 0.77 | MYC (0.47) | POLBGAANPC1RAB9AKMT2A | |
| SCHEMBL1854636 | 0.77 | NPC1 (0.46) | POLBGAANPC1RAB9AKMT2A | |
| SCHEMBL28897597 | 0.76 | AKR1C3 (0.64) | POLBGAANPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379518-B1 | THIADIAZOLE-SUBSTITUTED ARYLAMIDES | HOFFMANN LA ROCHE (CH) | 2014-05-07 | — | — | EP | disclosed |