Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.55 |
| ▸ | KDM4C | Q9H3R0 | 18/20 | 0.54 |
| ▸ | KDM2B | Q8NHM5 | 5/20 | 0.54 |
| ▸ | KDM5A | P29375 | 14/20 | 0.51 |
| ▸ | KDM5B | Q9UGL1 | 12/20 | 0.51 |
| ▸ | KDM4A | O75164 | 4/20 | 0.50 |
| ▸ | KDM5C | P41229 | 1/20 | 0.48 |
| ▸ | GABRP | O00591 | 1/20 | 0.47 |
| ▸ | GABRD | O14764 | 1/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.47 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.47 |
| ▸ | GABRE | P78334 | 1/20 | 0.47 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1568266 | 0.83 | KDM4C (0.50) | PIK3CAKDM4CKDM5AKDM5BKDM5C | |
| SCHEMBL17263330 | 0.80 | PIK3CA (0.61) | PIK3CA | |
| SCHEMBL24473869 | 0.79 | ALDH1A1 (0.56) | PIK3CAKDM4CKDM2BKDM5AKDM5B | |
| SCHEMBL28466905 | 0.77 | PIK3CA (0.68) | PIK3CAKDM4CKDM2BKDM5AKDM5B | |
| SCHEMBL20909892 | 0.76 | CCR1 (0.47) | — | |
| SCHEMBL1516867 | 0.74 | PIK3CA (0.74) | PIK3CAKDM4CKDM2BKDM5AKDM5B | |
| SCHEMBL31143236 | 0.74 | PIK3CA (0.74) | PIK3CAKDM4CKDM2BKDM5AKDM5B | |
| SCHEMBL30422164 | 0.74 | ALDH1A1 (0.61) | — | |
| SCHEMBL12169427 | 0.74 | ALDH1A1 (0.61) | — | |
| Hydrochloric Acid SCHEMBL1252523 | 0.73 | PIK3CA (0.72) | PIK3CAKDM4CKDM2BKDM5AKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160289191-A1 | ORGANIC COMPOUNDS | XENON PHARMACEUTICALS INC. (CA) | 2016-10-06 | — | — | US | disclosed |
| US-9187426-B2 | Organic compounds | NOVARTIS AG (CH) | 2015-11-17 | — | — | US | disclosed |
| US-20110105530-A1 | ORGANIC COMPOUNDS | XENON PHARMACEUTICALS INC. (CA) | 2011-05-05 | — | — | US | disclosed |
| EP-2307379-A2 | ORGANIC COMPOUNDS | Novartis AG (CH) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009156484-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105530-A1 | ORGANIC COMPOUNDS | SCD, SCD5, FADS2 | PIK3CA 2130/4885KDM4C 533/4885KDM2B 972/4885 |
| US-20160289191-A1 | ORGANIC COMPOUNDS | SCD, SCD5, FADS2 | PIK3CA 2130/4885KDM4C 533/4885KDM2B 972/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.