Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.69 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | FNTA | P49354 | 1/20 | 0.43 |
| ▸ | FNTB | P49356 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16625906 | 0.87 | CHRNB2 (0.65) | CHRNB2CHRNA4LMNACHRNA7MAPK1 | |
| SCHEMBL10028665 | 0.85 | CHRNB2 (0.85) | CHRNB2CHRNA4LMNACHRNA7MAPK1 | |
| SCHEMBL13509698 | 0.83 | CHRNB2 (0.59) | CHRNB2CHRNA4LMNACHRNA7MAPK1 | |
| SCHEMBL10570093 | 0.82 | CHRNB2 (0.63) | CHRNB2CHRNA4LMNACHRNA7MAPK1 | |
| SCHEMBL6674571 | 0.82 | CHRNB2 (1.00) | CHRNB2CHRNA4LMNACHRNA7MAPK1 | |
| SCHEMBL30093157 | 0.82 | CHRNB2 (0.79) | CHRNB2CHRNA4LMNACHRNA7MAPK1 | |
| SCHEMBL31044635 | 0.82 | CHRNB2 (1.00) | CHRNB2CHRNA4LMNACHRNA7MAPK1 | |
| SCHEMBL19750347 | 0.81 | CHRNB2 (0.56) | CHRNB2CHRNA4LMNACHRNA7ALDH1A1 | |
| SCHEMBL17886000 | 0.79 | CHRNB2 (0.53) | CHRNB2CHRNA4LMNACHRNA7ALDH1A1 | |
| SCHEMBL21278464 | 0.79 | CHRNB2 (0.73) | CHRNB2CHRNA4LMNACHRNA7MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11548870-B2 | Compounds useful as inhibitors of helios protein | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-01-10 | — | — | US | disclosed |
| US-20210147383-A1 | COMPOUNDS USEFUL AS INHIBITORS OF HELIOS PROTEIN | BRISTOL-MYERS SQUIBB COMPANY | 2021-05-20 | — | — | US | disclosed |
| US-9850276-B2 | Bidentate-binding modulators of LRRK2 and JNK kinases | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-12-26 | — | — | US | disclosed |
| US-20160185818-A1 | BIDENTATE-BINDING MODULATORS OF LRRK2 AND JNK KINASES | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2016-06-30 | — | — | US | disclosed |
| US-9072696-B2 | Cyclic peptides and use as medicines | NOVARTIS AG (CH) | 2015-07-07 | — | — | US | disclosed |
| US-20140134132-A1 | CYCLIC PEPTIDES AND USE AS MEDICINES | NOVARTIS AG (CH) | 2014-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160185818-A1 | BIDENTATE-BINDING MODULATORS OF LRRK2 AND JNK KINASES | LRRK2, PINK1, MAP2K3 | CHRNB2 3743/4885CHRNA4 3741/4885LMNA 3258/4885 |
| US-20210147383-A1 | COMPOUNDS USEFUL AS INHIBITORS OF HELIOS PROTEIN | IKZF2, RPL6, HNRNPR | CHRNB2 4567/4885CHRNA4 4740/4885LMNA 1301/4885 |
| US-20140134132-A1 | CYCLIC PEPTIDES AND USE AS MEDICINES | PPIF, VIP, FKBP1B | CHRNB2 1167/4885CHRNA4 1497/4885LMNA 2696/4885 |
| US-11548870-B2 | Compounds useful as inhibitors of helios protein | IKZF2, RPL6, HNRNPR | CHRNB2 4567/4885CHRNA4 4740/4885LMNA 1301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.