Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.61 |
| ▸ | ESR1 | P03372 | 4/20 | 0.59 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | F13A1 | P00488 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | HTR3A | P46098 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14230075 | 0.88 | ESR1 (0.52) | TMEM97SIGMAR1ESR1ESR2KDM4E | |
| SCHEMBL7381628 | 0.80 | TMEM97 (0.67) | TMEM97SIGMAR1ESR1ESR2KDM4E | |
| SCHEMBL1091362 | 0.78 | TMEM97 (0.64) | TMEM97SIGMAR1ESR1ESR2KDM4E | |
| SCHEMBL449737 | 0.76 | ESR1 (0.77) | ESR1ESR2KDM4ECA2ADRA2A | |
| SCHEMBL245139 | 0.76 | ESR1 (0.77) | TMEM97SIGMAR1ESR1ESR2KDM4E | |
| SCHEMBL1171041 | 0.76 | ESR1 (0.77) | TMEM97SIGMAR1ESR1ESR2KDM4E | |
| SCHEMBL17919346 | 0.76 | TAAR1 (0.50) | CA2ALDH1A1TAAR1NPC1CYP1A2 | |
| SCHEMBL274906 | 0.76 | TMEM97 (1.00) | TMEM97SIGMAR1ESR1ESR2KDM4E | |
| SCHEMBL29690338 | 0.76 | TMEM97 (0.61) | TMEM97SIGMAR1ESR1ESR2KDM4E | |
| SCHEMBL20831067 | 0.76 | TMEM97 (0.61) | TMEM97SIGMAR1ESR1ESR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9522908-B2 | Ezrin inhibitors and methods of making and using | Gerogetown University (US) | 2016-12-20 | — | — | US | disclosed |
| US-20140135325-A1 | NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING | GEORGETOWN UNIVERSITY (US) | 2014-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140135325-A1 | NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING | EZR, NHERF1, ERMP1 | TMEM97 3085/4885SIGMAR1 3981/4885ESR1 1364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.