Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 5/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MPO | P05164 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1395757 | 0.91 | ALDH1A1 (0.44) | ICMTP2RX7ALDH1A1CYP3A4KDM4E | |
| SCHEMBL29718887 | 0.91 | ALDH1A1 (0.44) | ICMTP2RX7ALDH1A1CYP3A4KDM4E | |
| SCHEMBL1570497 | 0.85 | TAAR1 (0.52) | TAAR1KMT2AMPOSLC6A4ALOX15 | |
| Acetic Acid SCHEMBL7415533 | 0.84 | MEN1 (0.47) | P2RX7TAAR1ALDH1A1CYP3A4KDM4E | |
| Hydrochloric Acid SCHEMBL2211929 | 0.84 | TAAR1 (0.50) | TAAR1KDM4EMEN1MAPTMAPK1 | |
| SCHEMBL2831742 | 0.81 | MPO (0.54) | P2RX7ALDH1A1CYP3A4KDM4EMEN1 | |
| SCHEMBL837008 | 0.79 | ALDH1A1 (0.46) | P2RX7ALDH1A1CYP3A4KDM4EMEN1 | |
| SCHEMBL29852214 | 0.77 | ICMT (0.43) | ICMTP2RX7ALDH1A1CYP3A4KDM4E | |
| SCHEMBL1115269 | 0.77 | MAPK8 (0.52) | ICMTP2RX7KDM4EMPOSLC6A4 | |
| SCHEMBL30148003 | 0.77 | MAPK8 (0.52) | ICMTP2RX7KDM4EMPOSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307397-A1 | 6-SUBSTITUTED PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | Array Biopharma, Inc. (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009158426-A1 | 6-SUBSTITUTED PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | ARRAY BIOPHARMA INC. (US) | 2009-12-30 | — | — | WO | disclosed |