Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | NPY5R | Q15761 | 9/20 | 0.47 |
| ▸ | AVPR1A | P37288 | 8/20 | 0.47 |
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8777675 | 0.88 | SIGMAR1 (0.61) | SIGMAR1NPY5RAVPR1ACFTRGOPC | |
| SCHEMBL10252829 | 0.85 | SIGMAR1 (0.58) | SIGMAR1NPY5RAVPR1ACFTRGOPC | |
| SCHEMBL6427482 | 0.83 | SIGMAR1 (0.56) | SIGMAR1NPY5RAVPR1ACFTRGOPC | |
| SCHEMBL18854250 | 0.81 | SIGMAR1 (0.55) | SIGMAR1NPY5RAVPR1ACFTRGOPC | |
| SCHEMBL612153 | 0.81 | SIGMAR1 (0.55) | SIGMAR1NPY5RAVPR1ACFTRGOPC | |
| SCHEMBL11839999 | 0.80 | SIGMAR1 (0.54) | SIGMAR1NPY5RAVPR1ACFTRGOPC | |
| SCHEMBL171980 | 0.80 | SIGMAR1 (0.54) | SIGMAR1NPY5RAVPR1ACFTRGOPC | |
| SCHEMBL15076889 | 0.80 | SIGMAR1 (0.54) | SIGMAR1NPY5RAVPR1ACFTRGOPC | |
| SCHEMBL29674557 | 0.80 | SIGMAR1 (0.54) | SIGMAR1NPY5RAVPR1ACFTRGOPC | |
| SCHEMBL3401467 | 0.80 | SIGMAR1 (0.54) | SIGMAR1NPY5RAVPR1ACFTRGOPC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3470396-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2019-04-17 | — | — | EP | claimed |
| EP-3165520-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme Inc (US) | 2017-05-10 | — | — | EP | claimed |
| US-20160332969-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. | 2016-11-17 | — | — | US | claimed |
| EP-3470396-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2019-04-17 | — | — | EP | disclosed |
| EP-2935214-B1 | 1,4-PYRIDONE COMPOUNDS | EPIZYME INC (US) | 2019-02-20 | — | — | EP | disclosed |
| US-10150764-B2 | Substituted benzene compounds | Epizyme, Inc. (US) | 2018-12-11 | — | — | US | disclosed |
| EP-3022184-B1 | SUBSTITUTED BENZENE COMPOUNDS | EPIZYME INC (US) | 2017-09-27 | — | — | EP | disclosed |
| EP-3165520-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme Inc (US) | 2017-05-10 | — | — | EP | disclosed |
| US-20160332969-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. | 2016-11-17 | — | — | US | disclosed |
| US-20160244464-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. | 2016-08-25 | — | — | US | disclosed |
| US-20160194316-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. | 2016-07-07 | — | — | US | disclosed |
| US-9243001-B2 | Substituted benzene compounds | Epizyme, Inc. (US) | 2016-01-26 | — | — | US | disclosed |
| EP-2970281-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| US-20150344427-A1 | 1,4-PYRIDONE COMPOUNDS | Epizyme, Inc. (US) | 2015-12-03 | — | — | US | disclosed |
| EP-2935214-A1 | 1,4-PYRIDONE COMPOUNDS | Epizyme, Inc. (US) | 2015-10-28 | — | — | EP | disclosed |
| WO-2015010049-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2015-01-22 | — | — | WO | disclosed |
| WO-2014172044-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2014-10-23 | — | — | WO | disclosed |
| US-20140315945-A1 | Substituted Benzene Compounds | Epizyme, Inc. (US) | 2014-10-23 | — | — | US | disclosed |
| WO-2014100646-A1 | 1,4-PYRIDONE COMPOUNDS | Epizyme, Inc. (US) | 2014-06-26 | — | — | WO | disclosed |
| US-20140142083-A1 | Substituted Benzene Compounds | Epizyme, Inc. (US) | 2014-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150344427-A1 | 1,4-PYRIDONE COMPOUNDS | PDXK, PNPO, PLPBP | SIGMAR1 1992/4885NPY5R 1140/4885AVPR1A 3253/4885 |
| US-20140315945-A1 | Substituted Benzene Compounds | VHL, AHR, TP53 | SIGMAR1 2881/4885NPY5R 1329/4885AVPR1A 4380/4885 |
| US-20160194316-A1 | SUBSTITUTED BENZENE COMPOUNDS | CYP1B1, TP53, VHL | SIGMAR1 2168/4885NPY5R 1639/4885AVPR1A 4142/4885 |
| US-20140142083-A1 | Substituted Benzene Compounds | CYP1B1, TP53, VHL | SIGMAR1 2168/4885NPY5R 1639/4885AVPR1A 4142/4885 |
| US-10150764-B2 | Substituted benzene compounds | CYP1B1, TP53, VHL | SIGMAR1 2168/4885NPY5R 1639/4885AVPR1A 4142/4885 |
| US-20160244464-A1 | SUBSTITUTED BENZENE COMPOUNDS | VHL, AHR, TP53 | SIGMAR1 2881/4885NPY5R 1329/4885AVPR1A 4380/4885 |
| US-20160332969-A1 | SUBSTITUTED BENZENE COMPOUNDS | CYP1B1, TP53, VHL | SIGMAR1 2168/4885NPY5R 1639/4885AVPR1A 4142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.