SCHEMBL157121

SCHEMBL157121

COC(=O)c1cccc(O)c1C(=O)OC

nearest known ligand 0.80

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 7/20 0.80
CA2 P00918 7/20 0.80
CA9 Q16790 7/20 0.80
CA12 O43570 6/20 0.80
CA7 P43166 6/20 0.80
CA14 Q9ULX7 6/20 0.80
LMNA P02545 1/20 0.68
TSHR P16473 1/20 0.68
HSD17B10 Q99714 2/20 0.50
ALDH1A1 P00352 1/20 0.50
CFTR P13569 1/20 0.50
CA5A P35218 1/20 0.49
KDM4E B2RXH2 2/20 0.48
POLB P06746 1/20 0.48
ATM Q13315 1/20 0.48
PDK2 Q15119 1/20 0.48
PDK4 Q16654 1/20 0.48
THRB P10828 1/20 0.48
PRKCG P05129 1/20 0.46
PRKCB P05771 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29453452 1.00 CA1 (0.80) CA1CA2CA9CA12CA7
SCHEMBL1519936 0.89 CA12 (1.00) CA1CA2CA9CA12CA7
SCHEMBL7824586 0.89 CA1 (0.74) CA1CA2CA9CA12CA7
SCHEMBL19709542 0.89 CA1 (0.74) CA1CA2CA9CA12CA7
SCHEMBL30995708 0.89 CA1 (0.68) CA1CA2CA9CA12CA7
SCHEMBL1666445 0.87 CA1 (0.64) CA1CA2CA9CA12CA7
SCHEMBL4186368 0.87 CA1 (0.66) CA1CA2CA9CA12CA7
SCHEMBL7838104 0.84 CA12 (0.67) CA1CA2CA9CA12CA7
SCHEMBL6865290 0.84 CA12 (0.56) CA1CA2CA9CA12CA7
SCHEMBL3576571 0.83 CA1 (0.59) CA1CA2CA9CA12CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 277 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7635662-B2 Compound for color-producing composition, and recording material CHEMIPRO KASEI KAISHA, LTD. (JP) 2009-12-22 US claimed
US-4929530-A OXIDATIVE LEUCO DYES, PHOTO-OXIDIZERS, REDUCING AGENTS, ORGANIC SULFONAMIDES AND PHENOLIC COMPONENTS; EXPOSING TO LIGHT FUJI PHOTO FILM CO., LTD. (JP) 1990-05-29 US claimed
US-12023385-B2 Tunable endogenous protein degradation with heterobifunctional compounds DANA-FARBER CANCER INSTITUTE, INC. (US) 2024-07-02 US disclosed
US-20240131169-A1 CLIPTAC COMPOSITION OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2024-04-25 US disclosed
US-11932616-B2 Diels-Alder ring-opening process NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) 2024-03-19 US disclosed
EP-4289838-A2 ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME Celgene Corporation (US) 2023-12-13 EP disclosed
US-11786600-B2 Cliptac composition OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2023-10-17 US disclosed
US-11786600-B2 Cliptac composition OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2023-10-17 US disclosed
US-11786600-B2 Cliptac composition OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2023-10-17 US disclosed
EP-3599236-B1 ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME CELGENE CORP (US) 2023-08-23 EP disclosed
EP-3256470-B1 METHODS TO INDUCE TARGETED PROTEIN DEGRADATION THROUGH BIFUNCTIONAL MOLECULES DANA FARBER CANCER INST INC (US) 2023-07-26 EP disclosed
US-4749679-A Heat sensitive recording materials FUJI PHOTO FILM CO., LTD. (JP) 1988-06-07 US disclosed
US-4682194-A MICROCAPSULES CONTAINING LEUCO DYE FUJI PHOTO FILM CO., LTD. (JP) 1987-07-21 US disclosed
US-4645844-A Functionally substituted phenoxyalkyl alkoxysilanes and method for preparing same M&T CHEMICALS INC. (US) 1987-02-24 US disclosed
US-4644376-A Heat-sensitive recording material FUJI PHOTO FILM CO., LTD. (JP) 1987-02-17 US disclosed
EP-0083839-B1 PROCESS FOR PRODUCING INORGANIC FIBER SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1986-03-05 EP disclosed
US-4495121-A SPINNING A POLYMETALOXANE, CALCINING SUMITOMO CHEMICAL COMPANY, LTD. (JP) 1985-01-22 US disclosed
EP-0083839-A2 Process for producing inorganic fiber SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1983-07-20 EP disclosed
US-4310527-A DISORDERS OF CAROIAC RHYTHM AND CORONARY HEART DISEASES AND HYDPERTENSION CIBA-GEIGY CORPORATION (US) 1982-01-12 US disclosed
US-4140789-A ADRENERGIC BLOCKING AGENTS, CARDIOTONIC, ANTIARRHYTHMIA, HYPOTENSIVE CIBA-GEIGY CORPORATION (US) 1979-02-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12023385-B2 Tunable endogenous protein degradation with heterobifunctional compounds DBN1, MYCBP, PSMG3 CA1 4322/4885CA2 4679/4885CA9 4408/4885
US-11786600-B2 Cliptac composition UBE3C, CBLC, STUB1 CA1 3846/4885CA2 4609/4885CA9 4608/4885
US-20240131169-A1 CLIPTAC COMPOSITION UBE3C, CBLC, STUB1 CA1 3846/4885CA2 4609/4885CA9 4608/4885
US-11932616-B2 Diels-Alder ring-opening process SQLE, GFER, OXER1 CA1 238/4885CA2 1164/4885CA9 2141/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.