Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOL1 | O14791 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | GRN | P28799 | 1/20 | 0.30 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.30 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.30 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3666639 | 0.70 | SLC2A1 (0.35) | APOL1 | |
| SCHEMBL15717438 | 0.67 | TAS1R3 (0.40) | APOL1OPRK1P2RX7 | |
| SCHEMBL19973579 | 0.64 | FADS1 (0.48) | — | |
| SCHEMBL3729303 | 0.63 | APOL1 (0.32) | APOL1 | |
| SCHEMBL1872257 | 0.62 | BDKRB1 (0.46) | OPRK1 | |
| SCHEMBL19973434 | 0.62 | TP53 (0.46) | — | |
| Hydrochloric Acid SCHEMBL1873147 | 0.61 | BDKRB1 (0.45) | OPRK1 | |
| SCHEMBL14778920 | 0.61 | CCR2 (0.50) | — | |
| SCHEMBL3936733 | 0.61 | CCR2 (0.50) | — | |
| SCHEMBL7383773 | 0.61 | CCR2 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2920166-A1 | BICYCLIC UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF PAIN | Array Biopharma, Inc. (US) | 2015-09-23 | — | — | EP | disclosed |
| WO-2014078454-A1 | BICYCLIC UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF PAIN | ARRAY BIOPHARMA INC. (US) | 2014-05-22 | — | — | WO | disclosed |