Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PDE2A | O00408 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9203028 | 0.81 | MEN1 (0.52) | ALDH1A1LMNAMEN1KMT2APDE2A | |
| SCHEMBL14930399 | 0.77 | SMN1; SMN2 (0.51) | ALDH1A1LMNAMEN1KMT2APDE2A | |
| SCHEMBL13149845 | 0.74 | ALDH1A1 (0.52) | ALDH1A1MEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL14731436 | 0.74 | ALDH1A1 (0.52) | ALDH1A1LMNAMEN1KMT2APDE2A | |
| SCHEMBL14730827 | 0.74 | ALDH1A1 (0.52) | ALDH1A1LMNAMEN1KMT2APDE2A | |
| SCHEMBL13149376 | 0.71 | KDM4E (0.64) | ALDH1A1LMNASMN1; SMN2TSHRKDM4E | |
| SCHEMBL27637077 | 0.70 | SMN1; SMN2 (0.48) | ALDH1A1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL334463 | 0.69 | SMN1; SMN2 (0.47) | ALDH1A1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL286931 | 0.69 | KDM4E (0.58) | ALDH1A1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL13149368 | 0.69 | LMNA (0.56) | ALDH1A1LMNAMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014075392-A1 | PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | MERCK SHARP & DOHME CORP. (US) | 2014-05-22 | — | — | WO | claimed |