Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.64 |
| ▸ | PKM | P14618 | 2/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9203028 | 0.79 | MEN1 (0.52) | CYP2C19MAPK1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL13149845 | 0.78 | ALDH1A1 (0.52) | CYP1A2USP2SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL14930399 | 0.76 | SMN1; SMN2 (0.51) | KDM4EMAPTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL766329 | 0.75 | RBP4 (0.57) | CYP1A2CYP2C19CYP3A4ALDH1A1 | |
| SCHEMBL13149368 | 0.73 | LMNA (0.56) | KDM4EPKMHSD17B10CYP2C19MAPK1 | |
| SCHEMBL13242427 | 0.72 | NR2E1 (0.53) | NPSR1CYP1A2CYP2C19MAPTCYP3A4 | |
| SCHEMBL15718708 | 0.71 | ALDH1A1 (0.43) | KDM4ECYP1A2CYP2C19SMN1; SMN2CYP3A4 | |
| SCHEMBL1919434 | 0.71 | MEN1 (0.73) | KDM4EPKMHSD17B10SLC6A7CYP1A2 | |
| SCHEMBL27580589 | 0.70 | KDM4E (0.62) | KDM4EPKMHSD17B10SLC6A7CYP1A2 | |
| SCHEMBL13149735 | 0.70 | SIGMAR1 (0.57) | KDM4ELMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130072497-A1 | N- SUBSTITUTED PIPERAZINES | DOW AGROSCIENCES LLC (US) | 2013-03-21 | — | — | US | disclosed |
| US-20130072497-A1 | N- SUBSTITUTED PIPERAZINES | DOW AGROSCIENCES LLC (US) | 2013-03-21 | — | — | US | disclosed |
| US-8338430-B2 | N-substituted piperazines | DOW AGROSCIENCES, LLC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-8338430-B2 | N-substituted piperazines | DOW AGROSCIENCES, LLC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-20100234391-A1 | N-SUBSTITUTED PIPERAZINES | DOW AGROSCIENCES LLC (US) | 2010-09-16 | — | — | US | disclosed |
| US-20100234391-A1 | N-SUBSTITUTED PIPERAZINES | DOW AGROSCIENCES LLC (US) | 2010-09-16 | — | — | US | disclosed |
| US-7754724-B2 | N-substituted piperazines | DOW AGROSCIENCES LLC (US) | 2010-07-13 | — | — | US | disclosed |
| US-7754724-B2 | N-substituted piperazines | DOW AGROSCIENCES LLC (US) | 2010-07-13 | — | — | US | disclosed |
| US-20070004750-A1 | N-substituted piperazines | CORTEVA AGRISCIENCE LLC | 2007-01-04 | — | — | US | disclosed |
| US-20070004750-A1 | N-substituted piperazines | CORTEVA AGRISCIENCE LLC | 2007-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004750-A1 | N-substituted piperazines | PRXL2A, CNPY2, CYP4X1 | KDM4E 280/4885PKM 3265/4885NPSR1 89/4885 |
| US-20100234391-A1 | N-SUBSTITUTED PIPERAZINES | PRXL2A, CNPY2, CYP4X1 | KDM4E 280/4885PKM 3265/4885NPSR1 89/4885 |
| US-20130072497-A1 | N- SUBSTITUTED PIPERAZINES | PRXL2A, CNPY2, CYP4X1 | KDM4E 280/4885PKM 3265/4885NPSR1 89/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.