Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.42 |
| ▸ | LOX | P28300 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.38 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.37 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.37 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | HTR1D | P28221 | 2/20 | 0.36 |
| ▸ | HTR1B | P28222 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29211870 | 0.83 | LOXL2 (0.40) | LOXL2LOXCA2KCNQ2SMARCA2 | |
| SCHEMBL25318934 | 0.83 | ADAMTS4 (0.43) | LOXL2CA1CA2ADAMTS4MMP13 | |
| SCHEMBL28406146 | 0.82 | LOXL2 (0.42) | LOXL2LOXCA2KCNQ2SMARCA2 | |
| SCHEMBL17310149 | 0.79 | CA1 (0.40) | LOXL2LOXCA1CA2SMARCA2 | |
| SCHEMBL11945522 | 0.79 | CA1 (0.40) | CA1CA2HTR1AHTR1DHTR1B | |
| SCHEMBL27894825 | 0.77 | LOXL2 (0.50) | LOXL2LOXCA2SMARCA2SMARCA4 | |
| SCHEMBL23674532 | 0.77 | CA1 (0.39) | CA1CA2HTR1AHTR1DHTR1B | |
| SCHEMBL28741515 | 0.76 | HTR1D (0.40) | CA1CA2HTR1AHTR1DHTR1B | |
| SCHEMBL28741615 | 0.76 | RIPK2 (0.41) | CA1CA2HTR1AHTR1DHTR1B | |
| SCHEMBL30384914 | 0.74 | PDE4A (0.41) | CA1CA2HTR1AHTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2920150-B1 | PROCESS FOR THE PREPARATION OF 2-TRIFLUOROMETHYL ISONICOTINIC ACID AND ESTERS | HOFFMANN LA ROCHE (CH) | 2017-07-19 | — | — | EP | disclosed |
| US-9481650-B2 | Process for the preparation of 2-trifluoromethyl isonicotinic acid and esters | HOFFMANN LA ROCHE INC. (US) | 2016-11-01 | — | — | US | disclosed |
| US-20150291530-A1 | PROCESS FOR THE PREPARATION OF 2-TRIFLUOROMETHYL ISONICOTINIC ACID AND ESTERS | HOFFMANN-LA ROCHE INC. (US) | 2015-10-15 | — | — | US | disclosed |
| EP-2920150-A1 | PROCESS FOR THE PREPARATION OF 2-TRIFLUOROMETHYL ISONICOTINIC ACID AND ESTERS | F. Hoffmann-La Roche AG (CH) | 2015-09-23 | — | — | EP | disclosed |
| WO-2014076127-A1 | PROCESS FOR THE PREPARATION OF 2-TRIFLUOROMETHYL ISONICOTINIC ACID AND ESTERS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150291530-A1 | PROCESS FOR THE PREPARATION OF 2-TRIFLUOROMETHYL ISONICOTINIC ACID AND ESTERS | TAAR1, TAAR5, TSHR | LOXL2 4769/4885LOX 2488/4885CA1 766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.