Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.42 |
| ▸ | LOX | P28300 | 1/20 | 0.41 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.38 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.37 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.35 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | ALPI | P09923 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15720571 | 0.82 | LOXL2 (0.42) | LOXL2LOXKCNQ2ADAMTS4MMP13 | |
| SCHEMBL29211870 | 0.79 | LOXL2 (0.40) | LOXL2LOXKCNQ2ADAMTS4MMP13 | |
| SCHEMBL25373119 | 0.79 | CA2 (0.39) | LOXL2KCNQ2CA2MMP2MMP7 | |
| SCHEMBL1662471 | 0.78 | LOXL2 (0.49) | LOXL2LOXARALPLALPI | |
| SCHEMBL27737035 | 0.77 | UHRF1 (0.41) | KCNQ2CA2MMP2MMP7MMP9 | |
| SCHEMBL28825630 | 0.76 | MMP2 (0.42) | CA2MMP2MMP7MMP9MMP14 | |
| SCHEMBL28815392 | 0.76 | ALPI (0.43) | LOXL2LOXCA2MMP2MMP7 | |
| SCHEMBL10200740 | 0.76 | LOXL2 (0.46) | LOXL2LOXKCNQ2ARTGFBR1 | |
| SCHEMBL27871145 | 0.76 | CA2 (0.39) | LOXL2LOXCA2ARMMP2 | |
| SCHEMBL1662456 | 0.74 | CCR1 (0.55) | LOXL2LOXPTGS1PTGS2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116981665-A | Novel compounds | 思瑞万斯公司 | 2023-10-31 | — | — | CN | disclosed |
| CN-111032656-B | Heterocyclic compound kinase inhibitor and pharmaceutical composition and application thereof | 捷思英达医药技术（上海）有限公司 | 2022-12-02 | — | — | CN | disclosed |
| CN-112638917-A | Heterocyclic compounds as kinase inhibitors, compositions comprising the heterocyclic compounds, and methods of use thereof | 捷思英达控股有限公司 | 2021-04-09 | — | — | CN | disclosed |
| CN-111032656-A | Heterocyclic compound kinase inhibitor and pharmaceutical composition and application thereof | 捷思英达医药技术（上海）有限公司 | 2020-04-17 | — | — | CN | disclosed |