Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 1/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 8/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 6/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.40 |
| ▸ | CCNK | O75909 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15649934 | 0.85 | CDK9 (0.48) | KCNQ3KCNQ2CDK9GSK3AIRAK1 | |
| SCHEMBL30777928 | 0.85 | CDK9 (0.48) | KCNQ3KCNQ2CDK9GSK3AIRAK1 | |
| SCHEMBL23520267 | 0.83 | CDK9 (0.47) | CDK9GSK3AIRAK1CDK2CCNT1 | |
| SCHEMBL14785464 | 0.78 | CDK2 (0.50) | CDK9CDK2CCNT1CCNE1 | |
| SCHEMBL24770654 | 0.78 | CDK9 (0.47) | CDK9GSK3AIRAK1CDK2CCNT1 | |
| SCHEMBL15486181 | 0.77 | EGFR (0.38) | CDK9CCNT1GRIN1GRIN2BHRH4 | |
| SCHEMBL15682390 | 0.77 | F2RL1 (0.40) | CDK9GSK3AIRAK1CDK2CCNT1 | |
| SCHEMBL23520268 | 0.77 | CDK9 (0.50) | CDK9GSK3AIRAK1CDK2CCNT1 | |
| SCHEMBL21045724 | 0.76 | KCNQ3 (0.44) | KCNQ3KCNQ2AAK1L3MBTL1 | |
| SCHEMBL18416745 | 0.75 | HSP90AA1 (0.46) | KCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9877954-B2 | 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfoximine group | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-01-30 | — | — | US | disclosed |
| US-9877954-B2 | 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfoximine group | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-01-30 | — | — | US | disclosed |
| US-9877954-B2 | 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfoximine group | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-01-30 | — | — | US | disclosed |
| US-20170202815-A1 | 5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-07-20 | — | — | US | disclosed |
| US-20170202815-A1 | 5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-07-20 | — | — | US | disclosed |
| US-20170202815-A1 | 5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-07-20 | — | — | US | disclosed |
| US-9650340-B2 | 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfoximine group | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-05-16 | — | — | US | disclosed |
| US-9650340-B2 | 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfoximine group | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-05-16 | — | — | US | disclosed |
| US-9650340-B2 | 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfoximine group | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-05-16 | — | — | US | disclosed |
| EP-2928878-B1 | 5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP | Bayer Pharma AG (DE) | 2016-11-02 | — | — | EP | disclosed |
| EP-2928878-B1 | 5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP | Bayer Pharma AG (DE) | 2016-11-02 | — | — | EP | disclosed |
| US-20150291528-A1 | 5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP | BAYER PHARMA AKTIEGESELLSCHAFT (DE) | 2015-10-15 | — | — | US | disclosed |
| US-20150291528-A1 | 5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP | BAYER PHARMA AKTIEGESELLSCHAFT (DE) | 2015-10-15 | — | — | US | disclosed |
| US-20150291528-A1 | 5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP | BAYER PHARMA AKTIEGESELLSCHAFT (DE) | 2015-10-15 | — | — | US | disclosed |
| EP-2928878-A1 | 5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP | Bayer Pharma Aktiengesellschaft (DE) | 2015-10-14 | — | — | EP | disclosed |
| WO-2014076091-A1 | 5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2014-05-22 | — | — | WO | disclosed |
| WO-2014076091-A1 | 5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2014-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170202815-A1 | 5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP | PNPO, PLPBP, PDXK | KCNQ3 3115/4885KCNQ2 2306/4885CDK9 824/4885 |
| US-20150291528-A1 | 5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP | PNPO, PLPBP, PDXK | KCNQ3 3115/4885KCNQ2 2306/4885CDK9 824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.