Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHBG | P04278 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.38 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 2/20 | 0.35 |
| ▸ | LDHB | P07195 | 2/20 | 0.35 |
| ▸ | TPMT | P51580 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15957662 | 0.88 | CYP3A4 (0.47) | SHBGKDM4EL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL27646009 | 0.82 | KDM4E (0.62) | KDM4EL3MBTL1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL8735157 | 0.78 | L3MBTL1 (0.45) | KDM4EL3MBTL1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL16418738 | 0.75 | CYP4F2 (0.39) | SHBGKDM4ESMN1; SMN2CYP3A4ACHE | |
| SCHEMBL15957652 | 0.73 | SHBG (0.52) | SHBGKDM4ECASP6ACHEMAPT | |
| SCHEMBL5581994 | 0.73 | HMGB1 (0.59) | SHBGKDM4EL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL17586552 | 0.72 | PTGS1 (0.44) | KDM4EL3MBTL1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL10456973 | 0.71 | CYP3A4 (0.47) | KDM4EL3MBTL1ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL283462 | 0.71 | SHBG (0.80) | SHBGKDM4EALDH1A1CASP6ACHE | |
| SCHEMBL623350 | 0.71 | L3MBTL1 (0.49) | KDM4EL3MBTL1ALDH1A1CYP3A4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765039-B2 | Biaryl derivatives as bromodomain inhibitors | ZENITH EPIGENETICS LTD. (CA) | 2017-09-19 | — | — | US | disclosed |
| US-20140140956-A1 | BIARYL DERIVATIVES AS BROMODOMAIN INHIBITORS | RVX THERAPEUTICS INC. (CA) | 2014-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140140956-A1 | BIARYL DERIVATIVES AS BROMODOMAIN INHIBITORS | BRDT, BRD3, BRD4 | SHBG 4116/4885KDM4E 615/4885L3MBTL1 722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.