Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | FDPS | P14324 | 9/20 | 0.44 |
| ▸ | GGPS1 | O95749 | 4/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9359973 | 0.85 | CYP3A4 (0.50) | EP300TP53CYP3A4USP2HSP90AA1 | |
| SCHEMBL8855131 | 0.84 | KARS1 (0.51) | EP300TP53CYP3A4USP2MEN1 | |
| SCHEMBL8855191 | 0.84 | KARS1 (0.53) | TP53CYP3A4USP2KDM4EMEN1 | |
| SCHEMBL29574656 | 0.83 | FDPS (0.50) | EP300TP53CYP3A4USP2HSP90AA1 | |
| SCHEMBL29552794 | 0.82 | HIF1A (0.35) | EP300TP53USP2MEN1MAPT | |
| SCHEMBL9359538 | 0.77 | KARS1 (0.34) | EP300CYP3A4USP2MAPTFDPS | |
| SCHEMBL30090652 | 0.77 | KARS1 (0.34) | EP300CYP3A4USP2MAPTFDPS | |
| SCHEMBL9360372 | 0.77 | POLA1 (0.44) | EP300TP53CYP3A4MEN1KMT2A | |
| Royleanone SCHEMBL21291506 | 0.76 | CYP3A4 (0.44) | EP300TP53CYP3A4USP2HSP90AA1 | |
| Royleanone SCHEMBL16006778 | 0.76 | CYP3A4 (0.44) | EP300TP53CYP3A4USP2HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2735339-B1 | Extract and isolated compounds from Drechslera rostrata and/or Eurotium tonophilum for use as anti-leishmania-major agents | UNIV KING SAUD (SA) | 2014-10-22 | — | — | EP | disclosed |
| EP-2735339-A1 | Extract and isolated compounds from Drechslera rostrata and/or Eurotium tonophilum for use as anti-leishmania-major agents | King Saud University (SA) | 2014-05-28 | — | — | EP | disclosed |