Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 6/20 | 0.44 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.34 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MGAM | O43451 | 3/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30090652 | 0.82 | KARS1 (0.34) | CYP3A4KARS1EP300HIF1AEPAS1 | |
| SCHEMBL9359538 | 0.82 | KARS1 (0.34) | CYP3A4KARS1EP300HIF1AEPAS1 | |
| SCHEMBL8855131 | 0.82 | KARS1 (0.51) | POLA1TDP1TP53CYP3A4KARS1 | |
| SCHEMBL8855191 | 0.77 | KARS1 (0.53) | POLA1TP53CYP3A4KARS1LMNA | |
| SCHEMBL29552794 | 0.77 | HIF1A (0.35) | TP53NR1H4MEN1KMT2AEP300 | |
| SCHEMBL15732245 | 0.77 | EP300 (0.46) | TP53CYP3A4MEN1KMT2AEP300 | |
| SCHEMBL9363876 | 0.74 | KARS1 (0.38) | CYP3A4KARS1LMNAEP300 | |
| SCHEMBL9359973 | 0.74 | CYP3A4 (0.50) | TP53CYP3A4KARS1LMNAMEN1 | |
| SCHEMBL8855376 | 0.69 | SRD5A2 (0.35) | CYP3A4KARS1LMNAEP300HIF1A | |
| SCHEMBL29552971 | 0.69 | SRD5A2 (0.35) | CYP3A4KARS1LMNAEP300HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0472733-B1 | PHENANTHRENE DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 1994-12-28 | — | — | EP | disclosed |
| US-5192817-A | Interleukin-1 inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-03-09 | — | — | US | disclosed |
| EP-0472733-A1 | PHENANTHRENE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-03-04 | — | — | EP | disclosed |