Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLA1 | P09884 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15732245 | 0.84 | EP300 (0.46) | CYP3A4ALOX15MAPTUSP2EP300 | |
| SCHEMBL8855191 | 0.84 | KARS1 (0.53) | KARS1CYP3A4ALOX15MAPTUSP2 | |
| SCHEMBL9360372 | 0.82 | POLA1 (0.44) | KARS1CYP3A4EP300LMNAPOLA1 | |
| SCHEMBL9359538 | 0.82 | KARS1 (0.34) | KARS1CYP3A4ALOX15MAPTUSP2 | |
| SCHEMBL30090652 | 0.82 | KARS1 (0.34) | KARS1CYP3A4ALOX15MAPTUSP2 | |
| SCHEMBL9359973 | 0.81 | CYP3A4 (0.50) | KARS1CYP3A4MAPTUSP2EP300 | |
| SCHEMBL29552794 | 0.77 | HIF1A (0.35) | MAPTUSP2EP300MAPK1MEN1 | |
| SCHEMBL29552971 | 0.71 | SRD5A2 (0.35) | KARS1CYP3A4ALOX15MAPTCYP2C19 | |
| SCHEMBL8855376 | 0.71 | SRD5A2 (0.35) | KARS1CYP3A4ALOX15MAPTCYP2C19 | |
| SCHEMBL9363876 | 0.70 | KARS1 (0.38) | KARS1CYP3A4ALOX15MAPTCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5654343-A | NITRIC OXIDE SYNTHESIS INHIBITOR; TREATING ENDOTOXIC SHOCK | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-05 | — | — | US | disclosed |
| EP-0676196-A1 | NITROGEN MONOXIDE SYNTHESIS INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-10-11 | — | — | EP | disclosed |