Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1573947 | 0.87 | GAA (0.46) | GAAMEN1KMT2AKDM4ENPC1 | |
| SCHEMBL1573835 | 0.86 | GAA (0.45) | GAAMEN1KMT2AKDM4ENPC1 | |
| SCHEMBL1573823 | 0.86 | GAA (0.45) | GAAMEN1KMT2AKDM4ENPC1 | |
| SCHEMBL1574523 | 0.86 | ALDH1A1 (0.46) | GAAGSK3BMEN1KMT2AKDM4E | |
| SCHEMBL1573869 | 0.85 | HPGD (0.49) | GAANPC1TP53HPGDRAB9A | |
| SCHEMBL1573881 | 0.84 | GAA (0.43) | GAAMEN1KMT2AKDM4ENPC1 | |
| SCHEMBL1574490 | 0.84 | LIPE (0.50) | GAAGSK3BMEN1KMT2AKDM4E | |
| SCHEMBL1573892 | 0.84 | ALDH1A1 (0.46) | GAAMEN1KMT2AKDM4ENPC1 | |
| SCHEMBL1573600 | 0.83 | RAB9A (0.58) | GAAMEN1KMT2AKDM4ENPC1 | |
| SCHEMBL1576556 | 0.83 | ALDH1A1 (0.45) | GAAHPGDSMN1; SMN2ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713779-B1 | INDAZOLE DERIVATIVES AS INHIBITORS OF HORMONE-SENSITIVE LIPASES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-04-13 | — | — | EP | disclosed |