Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1573567 | 0.81 | KDM4E (0.47) | MAOAMAOBKDM4EALDH1A1HPGD | |
| SCHEMBL3332845 | 0.77 | SORT1 (0.48) | MAOAMAOBKDM4EALDH1A1HPGD | |
| SCHEMBL3332328 | 0.76 | HPGD (0.49) | MAOAMAOBKDM4EALDH1A1HPGD | |
| SCHEMBL5301989 | 0.76 | MAPT (0.55) | MAOAMAOBKDM4EALDH1A1HPGD | |
| SCHEMBL3976219 | 0.72 | MAOA (0.54) | MAOAMAOBKDM4EALDH1A1HPGD | |
| SCHEMBL9849594 | 0.70 | LMNA (0.49) | MAOAMAOBKDM4EALDH1A1KCNA5 | |
| SCHEMBL3556495 | 0.70 | MAOA (0.56) | MAOAMAOBKDM4EALDH1A1HPGD | |
| SCHEMBL3396367 | 0.69 | PLAU (0.53) | MAOAMAOBKDM4EALDH1A1HPGD | |
| SCHEMBL16564358 | 0.69 | HTR2B (0.38) | KDM4EPIM1CDK2GSK3BCDK5 | |
| SCHEMBL1310429 | 0.68 | MAOA (0.58) | MAOAMAOBKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2158201-B1 | DERIVATIVES OF 7-ALKYNYL-1,8-NAPHTHYRIDONES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI AVENTIS (FR) | 2011-04-13 | — | — | EP | disclosed |
| EP-2158201-A2 | DERIVATIVES OF 7-ALKYNYL-1,8-NAPHTHYRIDONES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | Sanofi-Aventis (FR) | 2010-03-03 | — | — | EP | disclosed |
| WO-2009007535-A2 | DERIVATIVES OF 7-ALKYNYL-1,8-NAPHTHYRIDONES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2009-01-15 | — | — | WO | disclosed |