Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | CTSB | P07858 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | TXNRD1 | Q16881 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1917607 | 0.84 | PIN1 (0.57) | CTSBPKMKDM4EALDH1A1HPGD | |
| SCHEMBL8134885 | 0.82 | PKM (0.61) | MAPTCTSBPKMKDM4EALDH1A1 | |
| SCHEMBL9537830 | 0.81 | TXNRD1 (0.52) | MAPTCTSBPKMTXNRD1ALDH1A1 | |
| SCHEMBL18319382 | 0.81 | MAPT (0.64) | MAPTTXNRD1KDM4EALDH1A1HPGD | |
| SCHEMBL5301730 | 0.79 | CTSB (0.49) | MAPTCTSBPKMMAOAMAOB | |
| SCHEMBL4892092 | 0.79 | MAPT (0.55) | MAPTTXNRD1KDM4EALDH1A1HTT | |
| SCHEMBL2272150 | 0.79 | MAPT (0.60) | MAPTPKMTXNRD1KDM4EALDH1A1 | |
| SCHEMBL3332328 | 0.77 | HPGD (0.49) | KDM4EALDH1A1HPGDMAOAMAOB | |
| SCHEMBL6870152 | 0.77 | CTSB (0.49) | MAPTCTSBPKMKDM4EALDH1A1 | |
| SCHEMBL1330877 | 0.76 | MAPT (0.49) | MAPTPKMALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007020521-A1 | PYRIDOYRAZINONES AS PDE-5 INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2007-02-22 | — | — | WO | disclosed |
| US-5066654-A | 2-aryl-3-heterocyclicmethyl-3H-imidazo[4,5-b]pyridines as anxiolytics and anticonvulsants | A. H. ROBINS COMPANY, INCORPORATED (US) | 1991-11-19 | — | — | US | disclosed |