Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 2/20 | 0.37 |
| ▸ | MAP2K4 | P45985 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | RBP4 | P02753 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1574020 | 0.85 | L3MBTL1 (0.47) | ROCK1AHR | |
| SCHEMBL1573781 | 0.81 | MAP2K4 (0.41) | ROCK1AHRMAP2K4MAPK1MAPK6 | |
| SCHEMBL1573919 | 0.81 | HRH4 (0.47) | MAP2K4MAPK1MAPK6ABL1BCR | |
| SCHEMBL1573920 | 0.79 | MAP2K4 (0.41) | ROCK1AHRMAP2K4MAPK1MAPK6 | |
| SCHEMBL2958195 | 0.78 | PRMT5 (0.38) | PRMT5WDR77ROCK1HSP90AA1HTR2A | |
| SCHEMBL1573862 | 0.78 | ALDH1A1 (0.44) | MAP2K4MAPK1MAPK6ABL1BCR | |
| SCHEMBL1574198 | 0.76 | TP53 (0.47) | MAP2K4MAPK1MAPK6ABL1BCR | |
| SCHEMBL1573854 | 0.76 | RBP4 (0.45) | MAP2K4MAPK1MAPK6ABL1BCR | |
| SCHEMBL1574048 | 0.76 | GRM4 (0.41) | MAP2K4MAPK1MAPK6ABL1BCR | |
| SCHEMBL1573971 | 0.76 | MAP2K4 (0.42) | MAP2K4MAPK1MAPK6ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713779-B1 | INDAZOLE DERIVATIVES AS INHIBITORS OF HORMONE-SENSITIVE LIPASES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-04-13 | — | — | EP | disclosed |