Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LIPE | Q05469 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1574083 | 0.87 | GABRA1 (0.48) | ALDH1A1HPGDSMN1; SMN2ROCK1ABHD6 | |
| SCHEMBL1573738 | 0.85 | PRMT5 (0.38) | ROCK1AHR | |
| SCHEMBL1573781 | 0.83 | MAP2K4 (0.41) | ALDH1A1ROCK1AHR | |
| SCHEMBL1573980 | 0.83 | ROCK1 (0.41) | L3MBTL1ROCK1AHR | |
| SCHEMBL1573919 | 0.81 | HRH4 (0.47) | ALDH1A1 | |
| SCHEMBL1573862 | 0.81 | ALDH1A1 (0.44) | ALDH1A1HPGDSMN1; SMN2RAB9AGAA | |
| SCHEMBL1574085 | 0.80 | ALOX15 (0.54) | ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL1574198 | 0.79 | TP53 (0.47) | SMN1; SMN2LIPE | |
| SCHEMBL1573854 | 0.79 | RBP4 (0.45) | — | |
| SCHEMBL1573920 | 0.79 | MAP2K4 (0.41) | ALDH1A1SMN1; SMN2ROCK1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713779-B1 | INDAZOLE DERIVATIVES AS INHIBITORS OF HORMONE-SENSITIVE LIPASES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-04-13 | — | — | EP | disclosed |