Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.40 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.33 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2964542 | 0.84 | GAA (0.39) | SMN1; SMN2HPGDRAB9AHTTALDH1A1 | |
| SCHEMBL16242498 | 0.80 | HPGD (0.35) | SMN1; SMN2HPGDRAB9AHTTALDH1A1 | |
| SCHEMBL1573982 | 0.77 | SMN1; SMN2 (0.46) | SMN1; SMN2HPGDRAB9AHTTALDH1A1 | |
| SCHEMBL1573961 | 0.72 | SMN1; SMN2 (0.39) | SMN1; SMN2HPGDRAB9AHTTALDH1A1 | |
| SCHEMBL1573858 | 0.70 | MAPT (0.43) | SMN1; SMN2HPGDRAB9AHTTALDH1A1 | |
| SCHEMBL2962458 | 0.69 | GAA (0.35) | SMN1; SMN2HPGDRAB9AHTTALDH1A1 | |
| SCHEMBL3025237 | 0.68 | FAAH (0.43) | SMN1; SMN2HPGDRAB9AHTTALDH1A1 | |
| SCHEMBL1574400 | 0.68 | CTSB (0.44) | SMN1; SMN2ALDH1A1TSHRKMT2A | |
| SCHEMBL1573842 | 0.66 | ACHE (0.47) | SMN1; SMN2HPGDRAB9AALDH1A1TP53 | |
| SCHEMBL1574115 | 0.65 | GAA (0.41) | SMN1; SMN2HPGDRAB9AHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713779-B1 | INDAZOLE DERIVATIVES AS INHIBITORS OF HORMONE-SENSITIVE LIPASES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-04-13 | — | — | EP | disclosed |
| CN-1914180-A | Indazole derivatives as hormone sensitive lipase inhibitors | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-02-14 | — | — | CN | disclosed |